@@ -3150,6 +3150,49 @@ (define-public r-decomplexdisease
based on the shared signatures.")
(license license:gpl3)))
+(define-public r-decomptumor2sig
+ (package
+ (name "r-decomptumor2sig")
+ (version "2.12.0")
+ (source (origin
+ (method url-fetch)
+ (uri (bioconductor-uri "decompTumor2Sig" version))
+ (sha256
+ (base32
+ "04hg9bbga2s8scjxfd8wjlmr45nzzvh8d6gr0w929sybx4nj2qz6"))))
+ (properties `((upstream-name . "decompTumor2Sig")))
+ (build-system r-build-system)
+ (inputs (list perl)) ;script/extractSpecColumns.pl
+ (propagated-inputs
+ (list r-biocgenerics
+ r-biostrings
+ r-bsgenome-hsapiens-ucsc-hg19
+ r-data-table
+ r-genomeinfodb
+ r-genomicfeatures
+ r-genomicranges
+ r-ggplot2
+ r-ggseqlogo
+ r-gridextra
+ r-matrix
+ r-plyr
+ r-quadprog
+ r-readxl
+ r-s4vectors
+ r-summarizedexperiment
+ r-txdb-hsapiens-ucsc-hg19-knowngene
+ r-variantannotation))
+ (native-inputs (list r-knitr))
+ (home-page "https://rmpiro.net/decompTumor2Sig/")
+ (synopsis "Decomposition of individual tumors into mutational signatures")
+ (description
+ "The package uses quadratic programming for signature refitting, i.e., to
+decompose the mutation catalog from an individual tumor sample into a set of given
+mutational signatures (either Alexandrov-model signatures or Shiraishi-model
+signatures), computing weights that reflect the contributions of the signatures
+to the mutation load of the tumor.")
+ (license license:gpl2)))
+
(define-public r-deconvr
(package
(name "r-deconvr")