diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index c4105c4685..dc84a8f8bc 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -212,6 +212,7 @@ (define-module (gnu packages python-xyz)
   #:use-module (gnu packages libusb)
   #:use-module (gnu packages linux)
   #:use-module (gnu packages llvm)
+  #:use-module (gnu packages logging)
   #:use-module (gnu packages machine-learning)
   #:use-module (gnu packages man)
   #:use-module (gnu packages markup)
@@ -33278,29 +33279,94 @@ (define-public python-misskey
 (define-public python-lief
   (package
     (name "python-lief")
-    (version "0.12.3")
+    (version "0.13.2")
     (source (origin
               (method git-fetch)
               (uri (git-reference
                     (url "https://github.com/lief-project/LIEF")
                     (commit version)))
               (file-name (git-file-name name version))
+              (modules '((guix build utils)))
+              (snippet
+               '(begin
+                  ;; Configure build for Python bindings.
+                  (substitute* "api/python/config-default.toml"
+                    (("(ninja         = )true" all m)
+                     (string-append m "false"))
+                    (("(parallel-jobs = )0" all m)
+                     (string-append m (number->string (parallel-job-count)))))
+                  ;; Unbundle third-party dependencies.
+                  (for-each delete-file
+                            (find-files "third-party/"
+                                        (string-join '("spdlog"
+                                                       "frozen"
+                                                       "json"
+                                                       "mbedtls"
+                                                       "pybind11"
+                                                       "utfcpp")
+                                                     "|" )))
+                  ;; Same in argument #:configure-flags.
+                  (substitute* "api/python/setup.py"
+                    (("self\\._get_third_party_opt\\(\\)")
+                     "[\"-DLIEF_EXTERNAL_SPDLOG=ON\",
+                       \"-DLIEF_OPT_FROZEN_EXTERNAL=ON\",
+                       \"-DLIEF_OPT_MBEDTLS_EXTERNAL=ON\",
+                       \"-DLIEF_OPT_NLOHMANN_JSON_EXTERNAL=ON\",
+                       \"-DLIEF_OPT_PYBIND11_EXTERNAL=ON\",
+                       \"-DLIEF_OPT_UTFCPP_EXTERNAL=ON\"]"))))
               (sha256
                (base32
-                "11i6hqmcjh56y554kqhl61698n9v66j2qk1c1g63mv2w07h2z661"))))
-    (build-system python-build-system)
-    (native-inputs (list cmake))
+                "0y48x358ppig5xp97ahcphfipx7cg9chldj2q5zrmn610fmi4zll"))))
+    (build-system cmake-build-system)
     (arguments
-     (list
-      #:tests? #f                  ;needs network
-      #:phases #~(modify-phases %standard-phases
-                   (replace 'build
-                     (lambda _
-                       (invoke
-                        "python" "setup.py" "--sdk" "build"
-                        (string-append
-                         "-j" (number->string (parallel-job-count)))))))))
-    (home-page "https://github.com/lief-project/LIEF")
+     (list #:modules
+           '((guix build utils)
+             (guix build cmake-build-system)
+             ((guix build python-build-system) #:prefix python:))
+           #:imported-modules
+           (append %cmake-build-system-modules
+                   '((guix build python-build-system)))
+           #:configure-flags
+           #~'("-DCMAKE_LINK_WHAT_YOU_USE=ON"
+               "-DBUILD_SHARED_LIBS=ON"
+               "-DLIEF_INSTALL_COMPILED_EXAMPLES=ON"
+               "-DLIEF_TESTS=ON"
+               ;; Unbundle third-party dependencies
+               "-DLIEF_EXTERNAL_SPDLOG=ON"
+               "-DLIEF_OPT_FROZEN_EXTERNAL=ON"
+               "-DLIEF_OPT_MBEDTLS_EXTERNAL=ON"
+               "-DLIEF_OPT_NLOHMANN_JSON_EXTERNAL=ON"
+               "-DLIEF_OPT_PYBIND11_EXTERNAL=ON"
+               "-DLIEF_OPT_UTFCPP_EXTERNAL=ON")
+           #:phases
+           ;; Phases from python-build-system, for Python bindings.
+           #~(modify-phases %standard-phases
+               (add-after 'install 'chdir
+                 (lambda _
+                   (chdir "../source/api/python/")))
+               (add-after 'chdir 'ensure-no-mtimes-pre-1980
+                 (assoc-ref python:%standard-phases 'ensure-no-mtimes-pre-1980))
+               (add-after 'ensure-no-mtimes-pre-1980 'enable-bytecode-determinism
+                 (assoc-ref python:%standard-phases 'enable-bytecode-determinism))
+               (add-after 'enable-bytecode-determinism 'ensure-no-cythonized-files
+                 (assoc-ref python:%standard-phases 'ensure-no-cythonized-files))
+               (add-after 'ensure-no-cythonized-files 'python-install
+                 (lambda* (#:key inputs outputs #:allow-other-keys)
+                   ((assoc-ref python:%standard-phases 'install)
+                    #:inputs inputs
+                    #:outputs outputs
+                    #:configure-flags '()
+                    #:use-setuptools? #t)))
+               (add-after 'python-install 'add-install-to-pythonpath
+                 (assoc-ref python:%standard-phases 'add-install-to-pythonpath))
+               (add-after 'add-install-to-pythonpath 'add-install-to-path
+                 (assoc-ref python:%standard-phases 'add-install-to-path))
+               (add-after 'add-install-to-path 'python-wrap
+                 (assoc-ref python:%standard-phases 'wrap)))))
+    (native-inputs (list python-minimal-wrapper python-tomli))
+    (inputs (list frozen mbedtls-apache nlohmann-json pybind11 utfcpp spdlog))
+    (outputs '("out" "python"))
+    (home-page "https://lief-project.github.io/")
     (synopsis "Library to instrument executable formats")
     (description
      "@code{python-lief} is a cross platform library which can parse, modify
@@ -33348,7 +33414,7 @@ (define-public shrinkwrap
            python-poetry-core
            python-pypa-build
            python-pytest))
-    (inputs (list python-lief python-sh))
+    (inputs (list `(,python-lief "python") python-sh))
     (home-page "https://github.com/fzakaria/shrinkwrap")
     (synopsis "Emboss needed dependencies on the top level executable")
     (description
