diff --git a/gnu/local.mk b/gnu/local.mk
index ecbae4bb53..ce0f1994c5 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1901,6 +1901,7 @@ dist_patch_DATA =						\
   %D%/packages/patches/python-3-hurd-configure.patch		\
   %D%/packages/patches/python-aionotify-0.2.0-py3.8.patch	\
   %D%/packages/patches/python-argcomplete-1.11.1-fish31.patch	\
+  %D%/packages/patches/python-capstone-fix-python-constants.patch	\
   %D%/packages/patches/python-cross-compile.patch		\
   %D%/packages/patches/python-configobj-setuptools.patch	\
   %D%/packages/patches/python-dateutil-pytest-compat.patch	\
diff --git a/gnu/packages/engineering.scm b/gnu/packages/engineering.scm
index 16f572909c..336c8b0e38 100644
--- a/gnu/packages/engineering.scm
+++ b/gnu/packages/engineering.scm
@@ -39,6 +39,7 @@
 ;;; Copyright © 2023 Theofilos Pechlivanis <theofilos.pechlivanis@gmail.com>
 ;;; Copyright © 2023 Sharlatan Hellseher <sharlatanus@gmail.com>
 ;;; Copyright © 2023 pinoaffe <pinoaffe@gmail.com>
+;;; Copyright © 2024 Sören Tempel <soeren@soeren-tempel.net>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -1815,6 +1816,7 @@ (define-public capstone
     (version "5.0.1")
     (source (origin
               (method git-fetch)
+              (patches (search-patches "python-capstone-fix-python-constants.patch"))
               (uri (git-reference
                     (url "https://github.com/capstone-engine/capstone")
                     (commit version)))
diff --git a/gnu/packages/patches/python-capstone-fix-python-constants.patch b/gnu/packages/patches/python-capstone-fix-python-constants.patch
new file mode 100644
index 0000000000..75100c6652
--- /dev/null
+++ b/gnu/packages/patches/python-capstone-fix-python-constants.patch
@@ -0,0 +1,84 @@
+Backport upstream patch fixing various constants in the Python bindings.
+
+Taken from: https://github.com/capstone-engine/capstone/commit/f180e176de3efb060db62820ff981d0291ea8525
+
+diff --git a/bindings/python/capstone/__init__.py b/bindings/python/capstone/__init__.py
+index bda2fdb6..52353c28 100755
+--- a/bindings/python/capstone/__init__.py
++++ b/bindings/python/capstone/__init__.py
+@@ -113,7 +113,6 @@ __all__ = [
+     'CS_OPT_SYNTAX_NOREGNAME',
+     'CS_OPT_SYNTAX_MASM',
+     'CS_OPT_SYNTAX_MOTOROLA',
+-    'CS_OPT_SYNTAX_CS_REG_ALIAS',
+ 
+     'CS_OPT_DETAIL',
+     'CS_OPT_MODE',
+@@ -152,19 +151,6 @@ __all__ = [
+     'CS_OP_REG',
+     'CS_OP_IMM',
+     'CS_OP_FP',
+-    'CS_OP_PRED',
+-    'CS_OP_RESERVED_5',
+-    'CS_OP_RESERVED_6',
+-    'CS_OP_RESERVED_7',
+-    'CS_OP_RESERVED_8',
+-    'CS_OP_RESERVED_9',
+-    'CS_OP_RESERVED_10',
+-    'CS_OP_RESERVED_11',
+-    'CS_OP_RESERVED_12',
+-    'CS_OP_RESERVED_13',
+-    'CS_OP_RESERVED_14',
+-    'CS_OP_RESERVED_15',
+-    'CS_OP_SPECIAL',
+     'CS_OP_MEM',
+ 
+     'CS_GRP_INVALID',
+@@ -298,26 +284,13 @@ CS_OPT_NO_BRANCH_OFFSET = 9  # ARM, prints branch immediates without offset.
+ 
+ # Capstone option value
+ CS_OPT_OFF = 0             # Turn OFF an option - default option of CS_OPT_DETAIL
+-CS_OPT_ON = 1 << 0              # Turn ON an option (CS_OPT_DETAIL)
++CS_OPT_ON = 3              # Turn ON an option (CS_OPT_DETAIL)
+ 
+ # Common instruction operand types - to be consistent across all architectures.
+ CS_OP_INVALID = 0  # uninitialized/invalid operand.
+ CS_OP_REG = 1  # Register operand.
+ CS_OP_IMM = 2  # Immediate operand.
+ CS_OP_FP  = 3  # Floating-Point operand.
+-CS_OP_PRED = 4  # Predicate operand.
+-CS_OP_RESERVED_5 = 5
+-CS_OP_RESERVED_6 = 6
+-CS_OP_RESERVED_7 = 7
+-CS_OP_RESERVED_8 = 8
+-CS_OP_RESERVED_9 = 9
+-CS_OP_RESERVED_10 = 10
+-CS_OP_RESERVED_11 = 11
+-CS_OP_RESERVED_12 = 12
+-CS_OP_RESERVED_13 = 13
+-CS_OP_RESERVED_14 = 14
+-CS_OP_RESERVED_15 = 15
+-CS_OP_SPECIAL = 0x10  # Special operands from archs
+ CS_OP_MEM = 0x80  # Memory operand. Can be ORed with another operand type.
+ 
+ # Common instruction groups - to be consistent across all architectures.
+@@ -336,13 +309,12 @@ CS_AC_READ     = (1 << 0) # Operand that is read from.
+ CS_AC_WRITE    = (1 << 1) # Operand that is written to.
+ 
+ # Capstone syntax value
+-CS_OPT_SYNTAX_DEFAULT = 1 << 1  # Default assembly syntax of all platforms (CS_OPT_SYNTAX)
+-CS_OPT_SYNTAX_INTEL = 1 << 2  # Intel X86 asm syntax - default syntax on X86 (CS_OPT_SYNTAX, CS_ARCH_X86)
+-CS_OPT_SYNTAX_ATT = 1 << 3  # ATT asm syntax (CS_OPT_SYNTAX, CS_ARCH_X86)
+-CS_OPT_SYNTAX_NOREGNAME = 1 << 4  # Asm syntax prints register name with only number - (CS_OPT_SYNTAX, CS_ARCH_PPC, CS_ARCH_ARM)
+-CS_OPT_SYNTAX_MASM = 1 << 5  # MASM syntax (CS_OPT_SYNTAX, CS_ARCH_X86)
+-CS_OPT_SYNTAX_MOTOROLA = 1 << 6  # MOS65XX use $ as hex prefix
+-CS_OPT_SYNTAX_CS_REG_ALIAS = 1 << 7  # Prints common register alias which are not defined in LLVM (ARM: r9 = sb etc.)
++CS_OPT_SYNTAX_DEFAULT = 0    # Default assembly syntax of all platforms (CS_OPT_SYNTAX)
++CS_OPT_SYNTAX_INTEL = 1    # Intel X86 asm syntax - default syntax on X86 (CS_OPT_SYNTAX, CS_ARCH_X86)
++CS_OPT_SYNTAX_ATT = 2      # ATT asm syntax (CS_OPT_SYNTAX, CS_ARCH_X86)
++CS_OPT_SYNTAX_NOREGNAME = 3   # Asm syntax prints register name with only number - (CS_OPT_SYNTAX, CS_ARCH_PPC, CS_ARCH_ARM)
++CS_OPT_SYNTAX_MASM = 4      # MASM syntax (CS_OPT_SYNTAX, CS_ARCH_X86)
++CS_OPT_SYNTAX_MOTOROLA = 5 # MOS65XX use $ as hex prefix
+ 
+ # Capstone error type
+ CS_ERR_OK = 0      # No error: everything was fine
