diff --git a/gnu/local.mk b/gnu/local.mk
index c0a5c721fc..6afb84b25c 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1367,6 +1367,7 @@ dist_patch_DATA =						\
   %D%/packages/patches/irrlicht-use-system-libs.patch		\
   %D%/packages/patches/irrlicht-link-against-needed-libs.patch	\
   %D%/packages/patches/isl-0.11.1-aarch64-support.patch	\
+  %D%/packages/patches/isync-openssl3-fix.patch	\
   %D%/packages/patches/itk-snap-alt-glibc-compat.patch		\
   %D%/packages/patches/jami-disable-integration-tests.patch	\
   %D%/packages/patches/jami-libjami-headers-search.patch	\
diff --git a/gnu/packages/mail.scm b/gnu/packages/mail.scm
index 82fa8bc711..e7ae1c693f 100644
--- a/gnu/packages/mail.scm
+++ b/gnu/packages/mail.scm
@@ -2275,7 +2275,10 @@ (define-public isync
        (uri (string-append "mirror://sourceforge/isync/isync/"
                            version "/isync-" version ".tar.gz"))
        (sha256 (base32
-                "1zq0wwvmqsl9y71546dr0aygzn9gjjfiw19hlcq87s929y4p6ckw"))))
+                "1zq0wwvmqsl9y71546dr0aygzn9gjjfiw19hlcq87s929y4p6ckw"))
+       (patches
+        ;; Likely to be included in next version
+        (search-patches "isync-openssl3-fix.patch"))))
     (build-system gnu-build-system)
     (native-inputs
      (list perl))
diff --git a/gnu/packages/patches/isync-openssl3-fix.patch b/gnu/packages/patches/isync-openssl3-fix.patch
new file mode 100644
index 0000000000..6a2363e972
--- /dev/null
+++ b/gnu/packages/patches/isync-openssl3-fix.patch
@@ -0,0 +1,81 @@
+Upstream status: Taken from master branch.  Likely included in versions > 1.4.4
+
+Fixes issues with OpenSSL3.  See related thread:
+https://sourceforge.net/p/isync/mailman/isync-devel/thread/Y2jnr8hESp1PUW+6@bulldog/
+
+From b6c36624f04cd388873785c0631df3f2f9ac4bf0 Mon Sep 17 00:00:00 2001
+From: Oswald Buddenhagen <ossi@users.sf.net>
+Date: Mon, 6 Jun 2022 11:55:37 +0200
+Subject: [PATCH] work around "unexpected EOF" error messages at end of SSL
+ connections
+
+gmail apparently doesn't send a close notification (SSL_shutdown())
+before closing the TCP socket.
+---
+ src/drv_imap.c | 7 +++++--
+ src/socket.c   | 9 +++++++++
+ src/socket.h   | 1 +
+ 3 files changed, 15 insertions(+), 2 deletions(-)
+
+diff --git a/src/drv_imap.c b/src/drv_imap.c
+index fb8d165..6286045 100644
+--- a/src/drv_imap.c
++++ b/src/drv_imap.c
+@@ -1620,6 +1620,7 @@ imap_socket_read( void *aux )
+ 					error( "IMAP error: unexpected BYE response: %s\n", cmd );
+ 					/* We just wait for the server to close the connection now. */
+ 					ctx->expectEOF = 1;
++					socket_expect_eof( &ctx->conn );
+ 				} else {
+ 					/* We still need to wait for the LOGOUT's tagged OK. */
+ 				}
+@@ -1882,10 +1883,12 @@ static void
+ imap_cleanup_p2( imap_store_t *ctx,
+                  imap_cmd_t *cmd ATTR_UNUSED, int response )
+ {
+-	if (response == RESP_NO)
++	if (response == RESP_NO) {
+ 		imap_cancel_store( &ctx->gen );
+-	else if (response == RESP_OK)
++	} else if (response == RESP_OK) {
+ 		ctx->expectEOF = 1;
++		socket_expect_eof( &ctx->conn );
++	}
+ }
+ 
+ /******************* imap_open_store *******************/
+diff --git a/src/socket.c b/src/socket.c
+index ac3c847..892cece 100644
+--- a/src/socket.c
++++ b/src/socket.c
+@@ -810,6 +810,15 @@ socket_expect_activity( conn_t *conn, int expect )
+ 		conf_wakeup( &conn->fd_timeout, expect ? conn->conf->timeout : -1 );
+ }
+ 
++void
++socket_expect_eof( conn_t *sock )
++{
++#ifdef SSL_OP_IGNORE_UNEXPECTED_EOF  // implies HAVE_LIBSSL
++	if (sock->ssl)
++		SSL_set_options( sock->ssl, SSL_OP_IGNORE_UNEXPECTED_EOF );
++#endif
++}
++
+ int
+ socket_read( conn_t *conn, char *buf, uint len )
+ {
+diff --git a/src/socket.h b/src/socket.h
+index 5b1edd0..af679aa 100644
+--- a/src/socket.h
++++ b/src/socket.h
+@@ -142,6 +142,7 @@ void socket_start_tls(conn_t *conn, void (*cb)( int ok, void *aux ) );
+ void socket_start_deflate( conn_t *conn );
+ void socket_close( conn_t *sock );
+ void socket_expect_activity( conn_t *sock, int expect );
++void socket_expect_eof( conn_t *sock );
+ int socket_read( conn_t *sock, char *buf, uint len ); /* never waits */
+ char *socket_read_line( conn_t *sock ); /* don't free return value; never waits */
+ typedef enum { KeepOwn = 0, GiveOwn } ownership_t;
+-- 
+2.39.2
+
