diff --git a/gnu/packages/printers.scm b/gnu/packages/printers.scm
index e7761070e0..1abc99d64d 100644
--- a/gnu/packages/printers.scm
+++ b/gnu/packages/printers.scm
@@ -1,6 +1,7 @@
 ;;; GNU Guix --- Functional package management for GNU
 ;;; Copyright © 2018 Ludovic Courtès <ludo@gnu.org>
 ;;; Copyright © 2018 Tobias Geerinckx-Rice <me@tobias.gr>
+;;; Copyright © 2022 Morgan Smith <Morgan.J.Smith@outlook.com>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -18,13 +19,20 @@
 ;;; along with GNU Guix.  If not, see <http://www.gnu.org/licenses/>.
 
 (define-module (gnu packages printers)
+  #:use-module (guix gexp)
   #:use-module (guix packages)
   #:use-module (guix git-download)
   #:use-module (guix build-system gnu)
+  #:use-module (guix build-system python)
   #:use-module ((guix licenses) #:prefix license:)
+  #:use-module (gnu packages libffi)
   #:use-module (gnu packages libusb)
   #:use-module (gnu packages pkg-config)
-  #:use-module (gnu packages qt))
+  #:use-module (gnu packages python-xyz)
+  #:use-module (gnu packages qt)
+  #:use-module (gnu packages wxwidgets)
+  #:use-module (gnu packages xml)
+  #:use-module (gnu packages xorg))
 
 ;; This is a module for packages related to printer-like devices, but not
 ;; related to CUPS.
@@ -68,3 +76,65 @@ (define-public robocut
 with Graphtec and Sihouette plotting cutters using an SVG file as its input.")
     (home-page "http://robocut.org")
     (license license:gpl3+)))
+
+(define-public printrun
+  (package
+    (name "printrun")
+    (version "2.0.0rc8")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url "https://github.com/kliment/Printrun")
+                    (commit (string-append "printrun-" version))))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "0bvwrfhmn2km03fp343bd9ddjxv8sp3d0qdxk786rflw4yksbxgn"))))
+    (build-system python-build-system)
+    (arguments
+     (list #:phases #~(modify-phases %standard-phases
+                        (add-after 'unpack 'patch-files
+                          (lambda _
+                            (substitute* "requirements.txt"
+                              (("== 4.1.0")
+                               ">= 4.0.0")
+                              (("dbus-python.*")
+                               ""))
+                            (delete-file "printrun/power/osx.py")
+                            (delete-file "printrun/packer.py")
+                            (substitute* "printrun/utils.py"
+                              (("shared_pronterface_images_dir = .*")
+                               (string-append
+                                "shared_pronterface_images_dir = \""
+                                #$output "/share/pronterface/images\"\n"))
+                              (("shared_pixmaps_dir = .*")
+                               (string-append "shared_pixmaps_dir = \""
+                                              #$output "/share/pixmaps\"\n"))
+                              (("shared_pronterface_dir = .*")
+                               (string-append "shared_pixmaps_dir = \""
+                                              #$output
+                                              "/share/pronterface\"\n")))))
+                        (add-before 'check 'setup-display
+                          (lambda* (#:key tests? #:allow-other-keys)
+                            (when tests?
+                              (system "Xvfb :1 &")
+                              (setenv "DISPLAY" ":1")))))))
+    (inputs (list python-appdirs
+                  python-cairocffi
+                  python-cairosvg
+                  python-cffi
+                  python-dbus
+                  python-lxml
+                  python-numpy
+                  python-psutil
+                  python-pyglet
+                  python-pyserial
+                  python-wxpython))
+    (native-inputs (list python-cython xorg-server-for-tests))
+    (home-page "https://github.com/kliment/Printrun/")
+    (synopsis
+     "Printrun is a full suite of host interfaces for 3D printers and CNC")
+    (description
+     "Printrun consists of printcore, pronsole and pronterface, and a small
+collection of helpful scripts.")
+    (license license:gpl3+)))
