diff --git a/gnu/local.mk b/gnu/local.mk
index 62cfe230bb3..9929877bbbe 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1509,9 +1509,7 @@ dist_patch_DATA =						\
   %D%/packages/patches/gnupg-1-build-with-gcc10.patch		\
   %D%/packages/patches/gnutls-skip-trust-store-test.patch	\
   %D%/packages/patches/gobject-introspection-absolute-shlib-path.patch \
-  %D%/packages/patches/gobject-introspection-absolute-shlib-path-1.72.patch \
   %D%/packages/patches/gobject-introspection-cc.patch		\
-  %D%/packages/patches/gobject-introspection-cc-1.72.patch	\
   %D%/packages/patches/gobject-introspection-girepository.patch	\
   %D%/packages/patches/go-fix-script-tests.patch			\
   %D%/packages/patches/go-gopkg-in-yaml-v3-32bit.patch		\
diff --git a/gnu/packages/patches/gobject-introspection-absolute-shlib-path-1.72.patch b/gnu/packages/patches/gobject-introspection-absolute-shlib-path-1.72.patch
deleted file mode 100644
index 8bb86467c08..00000000000
--- a/gnu/packages/patches/gobject-introspection-absolute-shlib-path-1.72.patch
+++ /dev/null
@@ -1,173 +0,0 @@
-Names of libraries included in typelib files are opened by dlopen.
-Here we add the full path.
-
-This patch was provided by Luca Bruno <lucabru@src.gnome.org>,
-for 'gobject-introspection' 1.40.0 in Nix.
-
-It has since been updated to work with newer versions of
-gobject-introspection.
-
-diff --git a/giscanner/scannermain.py b/giscanner/scannermain.py
-index 1d39ab84..e12ed24e 100644
---- a/giscanner/scannermain.py
-+++ b/giscanner/scannermain.py
-@@ -95,6 +95,39 @@ def get_windows_option_group(parser):
-     return group
- 
- 
-+def _get_default_fallback_libpath():
-+    # Newer multiple-output-optimized stdenv has an environment variable
-+    # $outputLib which in turn specifies another variable which then is used as
-+    # the destination for the library contents (${!outputLib}/lib).
-+    store_path = os.environ.get(os.environ.get("outputLib")) if "outputLib" in os.environ else None
-+    if store_path is None:
-+        outputs = os.environ.get("outputs", "out").split()
-+        if "lib" in outputs:
-+            # For multiple output derivations let's try whether there is a $lib
-+            # environment variable and use that as the base store path.
-+            store_path = os.environ.get("lib")
-+        elif "out" in outputs:
-+            # Otherwise we have a single output derivation, so the libraries
-+            # most certainly will end up in "$out/lib".
-+            store_path = os.environ.get("out")
-+
-+    if store_path is not None:
-+        # Even if we have a $lib as output, there still should be a $lib/lib
-+        # directory.
-+        return os.path.join(store_path, 'lib')
-+    else:
-+        # If we haven't found a possible scenario, let's return an empty string
-+        # so that the shared library won't be prepended with a path.
-+        #
-+        # Note that this doesn't mean that all hope is lost, because after all
-+        # we can still use --fallback-library-path to set one.
-+        #
-+        # Also, we're not returning None, because that would make it very
-+        # difficult to disable adding fallback paths altogether using something
-+        # like: --fallback-library-path=""
-+        return ""
-+
-+
- def _get_option_parser():
-     parser = optparse.OptionParser('%prog [options] sources',
-                                    version='%prog ' + giscanner.__version__)
-@@ -220,6 +253,10 @@ match the namespace prefix.""")
-     parser.add_option("", "--compiler",
-                       action="store", dest="compiler", default=None,
-                       help="the C compiler to use internally")
-+    parser.add_option("", "--fallback-library-path",
-+                      action="store", dest="fallback_libpath",
-+                      default=_get_default_fallback_libpath(),
-+                      help="Path to prepend to unknown shared libraries")
- 
-     group = get_preprocessor_option_group(parser)
-     parser.add_option_group(group)
-diff --git a/giscanner/shlibs.py b/giscanner/shlibs.py
-index 9f8ab5df..8aa37c99 100644
---- a/giscanner/shlibs.py
-+++ b/giscanner/shlibs.py
-@@ -57,6 +57,14 @@ def _ldd_library_pattern(library_name):
-     $""" % re.escape(library_name), re.VERBOSE)
- 
- 
-+def _ldd_library_guix_pattern(library_name):
-+    store_dir = re.escape(
-+      os.environ.get("NIX_STORE", default="/gnu/store")
-+    )
-+    pattern = r'(%s(?:/[^/]*)+lib%s[^A-Za-z0-9_-][^\s\(\)]*)'
-+    return re.compile(pattern % (store_dir, re.escape(library_name)))
-+
-+
- # This is a what we do for non-la files. We assume that we are on an
- # ELF-like system where ldd exists and the soname extracted with ldd is
- # a filename that can be opened with dlopen().
-@@ -108,7 +116,8 @@ def _resolve_non_libtool(options, binary, libraries):
-             output = output.decode("utf-8", "replace")
- 
-         shlibs = resolve_from_ldd_output(libraries, output)
--        return list(map(sanitize_shlib_path, shlibs))
-+        fallback_libpath = options.fallback_libpath or "";
-+        return list(map(lambda p: os.path.join(fallback_libpath, p), map(sanitize_shlib_path, shlibs)))
- 
- 
- def sanitize_shlib_path(lib):
-@@ -117,19 +126,18 @@ def sanitize_shlib_path(lib):
-     # In case we get relative paths on macOS (like @rpath) then we fall
-     # back to the basename as well:
-     # https://gitlab.gnome.org/GNOME/gobject-introspection/issues/222
--    if sys.platform == "darwin":
--        if not os.path.isabs(lib):
--            return os.path.basename(lib)
--        return lib
--    else:
-+
-+    # Always use absolute paths if available
-+    if not os.path.isabs(lib):
-         return os.path.basename(lib)
-+    return lib
- 
- 
- def resolve_from_ldd_output(libraries, output):
-     patterns = {}
-     for library in libraries:
-         if not os.path.isfile(library):
--            patterns[library] = _ldd_library_pattern(library)
-+            patterns[library] = (_ldd_library_pattern(library), _ldd_library_guix_pattern(library))
-     if len(patterns) == 0:
-         return []
- 
-@@ -141,8 +149,12 @@ def resolve_from_ldd_output(libraries, output):
-         if line.endswith(':'):
-             continue
-         for word in line.split():
--            for library, pattern in patterns.items():
--                m = pattern.match(word)
-+            for library, (pattern, guix_pattern) in patterns.items():
-+                store_dir = os.environ.get("NIX_STORE", default="/gnu/store")
-+                if line.find(store_dir) != -1:
-+                    m = guix_pattern.match(word)
-+                else:
-+                    m = pattern.match(word)
-                 if m:
-                     del patterns[library]
-                     shlibs.append(m.group())
-diff --git a/giscanner/utils.py b/giscanner/utils.py
-index 31c7ea48..630002a8 100644
---- a/giscanner/utils.py
-+++ b/giscanner/utils.py
-@@ -114,16 +114,11 @@ def extract_libtool_shlib(la_file):
-     if dlname is None:
-         return None
- 
--    # Darwin uses absolute paths where possible; since the libtool files never
--    # contain absolute paths, use the libdir field
--    if platform.system() == 'Darwin':
--        dlbasename = os.path.basename(dlname)
--        libdir = _extract_libdir_field(la_file)
--        if libdir is None:
--            return dlbasename
--        return libdir + '/' + dlbasename
--    # Older libtools had a path rather than the raw dlname
--    return os.path.basename(dlname)
-+    dlbasename = os.path.basename(dlname)
-+    libdir = _extract_libdir_field(la_file)
-+    if libdir is None:
-+        return dlbasename
-+    return libdir + '/' + dlbasename
- 
- 
- # Returns arguments for invoking libtool, if applicable, otherwise None
-diff --git a/tests/scanner/test_shlibs.py b/tests/scanner/test_shlibs.py
-index a8337c60..7f123103 100644
---- a/tests/scanner/test_shlibs.py
-+++ b/tests/scanner/test_shlibs.py
-@@ -40,7 +40,8 @@ class TestLddParser(unittest.TestCase):
- 
-         self.assertEqual(
-             sanitize_shlib_path('/foo/bar'),
--            '/foo/bar' if sys.platform == 'darwin' else 'bar')
-+            # Always use an absolute filename for Guix
-+            '/foo/bar')
- 
-     def test_unresolved_library(self):
-         output = ''
diff --git a/gnu/packages/patches/gobject-introspection-cc-1.72.patch b/gnu/packages/patches/gobject-introspection-cc-1.72.patch
deleted file mode 100644
index d3b1df82af1..00000000000
--- a/gnu/packages/patches/gobject-introspection-cc-1.72.patch
+++ /dev/null
@@ -1,15 +0,0 @@
-Use gcc as the default C compiler if CC is not set.
-
-diff --git a/giscanner/__init__.py b/giscanner/__init__.py
-index 7c2f365a..607fe341 100644
---- a/giscanner/__init__.py
-+++ b/giscanner/__init__.py
-@@ -21,6 +21,8 @@ import os
- builddir = os.environ.get('UNINSTALLED_INTROSPECTION_BUILDDIR')
- if builddir is not None:
-     __path__.append(os.path.join(builddir, 'giscanner'))  # type: ignore  # mypy issue #1422
-+if not 'CC' in os.environ:
-+    os.environ['CC'] = 'gcc'
- try:
-     from ._version import __version__
- except ImportError:
