diff --git a/gnu/local.mk b/gnu/local.mk
index 51c4f41331..76bfedbb9c 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -309,6 +309,7 @@ GNU_SYSTEM_MODULES =				\
   %D%/packages/inklingreader.scm		\
   %D%/packages/inkscape.scm			\
   %D%/packages/installers.scm			\
+  %D%/packages/instrumentation.scm		\
   %D%/packages/ipfs.scm			\
   %D%/packages/irc.scm  			\
   %D%/packages/irods.scm  			\
diff --git a/gnu/packages/instrumentation.scm b/gnu/packages/instrumentation.scm
new file mode 100644
index 0000000000..d8de52facd
--- /dev/null
+++ b/gnu/packages/instrumentation.scm
@@ -0,0 +1,79 @@
+;;; GNU Guix --- Functional package management for GNU
+;;; Copyright © 2021 Olivier Dion <olivier.dion@polymtl.ca>
+;;;
+;;; This file is part of GNU Guix.
+;;;
+;;; GNU Guix is free software; you can redistribute it and/or modify it
+;;; under the terms of the GNU General Public License as published by
+;;; the Free Software Foundation; either version 3 of the License, or (at
+;;; your option) any later version.
+;;;
+;;; GNU Guix is distributed in the hope that it will be useful, but
+;;; WITHOUT ANY WARRANTY; without even the implied warranty of
+;;; MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+;;; GNU General Public License for more details.
+;;;
+;;; You should have received a copy of the GNU General Public License
+;;; along with GNU Guix.  If not, see <http://www.gnu.org/licenses/>.
+
+(define-module (gnu packages instrumentation)
+  #:use-module (gnu packages boost)
+  #:use-module (gnu packages elf)
+  #:use-module (gnu packages llvm)
+  #:use-module (gnu packages tbb)
+  #:use-module (guix build-system cmake)
+  #:use-module (guix download)
+  #:use-module (guix git-download)
+  #:use-module ((guix licenses) #:prefix license:)
+  #:use-module (guix packages))
+
+(define-public dyninst
+  (package
+    (name "dyninst")
+    ;; Newer versions are not promoted on main home page.
+    ;; Upgrade to 12.0.1 if anyone require a newer version.
+    (version "10.2.1")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url "https://github.com/dyninst/dyninst")
+                    (commit (string-append "v" version))))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32 "1m04pg824rqx647wvk9xl33ri8i6mm0vmrz9924li25dxbr4zqd5"))))
+
+    (build-system cmake-build-system)
+    (arguments
+     `(#:tests? #f
+       ;; STERILE_BUILD: Do not download/build third-party dependencies from
+       ;; source.
+       #:configure-flags
+       (list "-DSTERILE_BUILD=ON")
+       ;; NOTE: dyninst needs to search for shared libraries that are linked
+       ;; against the instrumented binary in order to rebuild the entire
+       ;; program.  For this purpose, one can use LD_LIBRARY_PATH or
+       ;; DYNISNT_REWRITER_PATHS environment variables to add paths for dyinst
+       ;; to search.  However, dyninst also tries to be smart by executing
+       ;; ldconfig, which is not portable.  If ldconfig is not available on
+       ;; the system, dyinst wrongly assumes that the shared libraries can not
+       ;; be found, even though it can.  This bad logic is still there with
+       ;; newer versions of dyinst.  Thus, this substitution makes the bad
+       ;; code path unreachable.
+       #:phases
+       (modify-phases %standard-phases
+         (add-after 'unpack 'patch-bad-logic
+           (lambda _
+             (substitute* "dyninstAPI/src/linux.C"
+               (("if\\(\\!fgets\\(buffer, 512, ldconfig\\)\\)")
+                "fgets(buffer, 512, ldconfig); if (false)")))))))
+    (propagated-inputs
+     `(("elfutils" ,elfutils)
+       ("boost" ,boost)
+       ("tbb" ,tbb-2020)))
+    (home-page "https://dyninst.org/")
+    (synopsis "Dynamic instrumentation")
+    (description "Dyninst is a collection of libraries for instrumenting,
+analyzing and editing binaries.  It can attach to an existing program or
+create a new one out of an ELF file for analysis or modification.  It come
+with a handful of C++ libraries.")
+    (license license:lgpl2.0)))
