diff --git a/gnu/packages/antivirus.scm b/gnu/packages/antivirus.scm
index 1a23657a61..b561ff060a 100644
--- a/gnu/packages/antivirus.scm
+++ b/gnu/packages/antivirus.scm
@@ -31,12 +31,17 @@ (define-module (gnu packages antivirus)
   #:use-module (gnu packages)
   #:use-module (gnu packages check)
   #:use-module (gnu packages compression)
+  #:use-module (gnu packages cmake)
+  #:use-module (gnu packages crates-crypto)
+  #:use-module (gnu packages crates-graphics)
+  #:use-module (gnu packages crates-io)
   #:use-module (gnu packages curl)
   #:use-module (gnu packages ncurses)
   #:use-module (gnu packages pcre)
   #:use-module (gnu packages pkg-config)
   #:use-module (gnu packages python)
   #:use-module (gnu packages python-check)
+  #:use-module (gnu packages rust-apps)
   #:use-module (gnu packages rust)
   #:use-module (gnu packages tls)
   #:use-module (gnu packages web)
@@ -62,49 +67,107 @@ (define-public clamav
               (snippet
                '(begin
                   (delete-file "Cargo.lock")
-                  (for-each
-                   delete-file
-                   (find-files ".cargo/vendor" ".cargo-checksum\\.json"))
                   (for-each delete-file-recursively
-                            '("win32"                  ; unnecessary
+                            '(".cargo"                 ; vendored rust inputs
+                              "win32"                  ; unnecessary
                               "libclamunrar"))))))     ; non-free license
-    (build-system cmake-build-system)
+    (build-system cargo-build-system)
     (arguments
-     (list
-      #:configure-flags
-      #~(list "-DENABLE_MILTER=OFF" "-DENABLE_UNRAR=OFF")
-      #:imported-modules `((guix build cargo-utils)
-                           ,@%cmake-build-system-modules)
-      #:phases
-      #~(modify-phases %standard-phases
-          (add-after 'unpack 'inject-rust-onenote
-            (lambda _
-              (substitute* "libclamav_rust/Cargo.toml"
-                (("onenote_parser = .*")
-                 "onenote_parser = \"0.3.1\"\n"))))
-          (add-after 'patch-source-shebangs 'patch-cargo-checksums
-            (lambda _
-              (use-modules
-               (srfi srfi-1) (ice-9 ftw) (guix build cargo-utils))
-              (with-directory-excursion ".cargo/vendor"
-                (for-each generate-all-checksums
-                          (delete "." (delete ".." (scandir ".")))))))
-          (add-after 'unpack 'skip-clamd-tests
-            ;; XXX: The check?_clamd tests fail inside the build
-            ;; chroot, but pass outside.
-            (lambda* (#:key tests? #:allow-other-keys)
-              (when tests?
-                (substitute* "unit_tests/CMakeLists.txt"
-                  (("clamd_test\\.py" test)
-                   (string-append
-                    test " -k \"not test_clamd_08_VirusEvent\"")))))))))
+     (let ((cargo-inputs
+            `(("rust-flate2" ,rust-flate2-1)
+              ("rust-hex" ,rust-hex-0.4)
+              ("rust-libc" ,rust-libc-0.2)
+              ("rust-log" ,rust-log-0.4)
+              ("rust-sha2" ,rust-sha2-0.10)
+              ("rust-tempfile" ,rust-tempfile-3)
+              ("rust-thiserror" ,rust-thiserror-1)
+              ("rust-image" ,rust-image-0.24)
+              ("rust-rustdct" ,rust-rustdct-0.7)
+              ("rust-transpose" ,rust-transpose-0.2)
+              ("rust-num-traits" ,rust-num-traits-0.2)
+              ("rust-base64" ,rust-base64-0.21)
+              ("rust-sha1" ,rust-sha1-0.10)
+              ("rust-unicode-segmentation" ,rust-unicode-segmentation-1)
+              ("rust-bindgen" ,rust-bindgen-0.66)
+              ("rust-onenote-parser" ,rust-onenote-parser-for-clamav)
+              ("rust-hex-literal" ,rust-hex-literal-0.4)
+              ("rust-inflate" ,rust-inflate-0.4)
+              ("rust-bzip2-rs" ,rust-bzip2-rs-0.1)
+              ("rust-byteorder" ,rust-byteorder-1)
+              ("rust-delharc" ,rust-delharc-0.6)))
+           (cargo-development-inputs
+            `(("rust-cbindgen" ,rust-cbindgen-0.26)
+              ("rust-bindgen" ,rust-bindgen-0.66))))
+       (list
+        #:cargo-inputs cargo-inputs
+        #:cargo-development-inputs cargo-development-inputs
+        #:vendor-dir ".cargo/vendor"
+        #:imported-modules `(,@%cmake-build-system-modules
+                             ,@%cargo-build-system-modules)
+        #:modules '((guix build cargo-build-system)
+                    ((guix build cmake-build-system) #:prefix cmake:)
+                    (guix build utils))
+        #:phases
+        #~(modify-phases %standard-phases
+            ;; There is a .exe file used in unit tests.
+            (delete 'check-for-pregenerated-files)
+            (add-after 'configure 'fix-cargo-inputs-vendoring
+              (lambda _
+                ;; Reproduce the original layout, fails with config.
+                (rename-file ".cargo/config" ".cargo/config.toml")
+                ;; Wrongly placed by configure
+                (delete-file-recursively
+                 (string-append ".cargo/vendor/clamav-" #$version ".tar.zst"))))
+            (add-after 'patch-cargo-checksums 'cmake-configure
+              (lambda* (#:key outputs #:allow-other-keys)
+                ((assoc-ref cmake:%standard-phases 'configure)
+                 #:configure-flags
+                 (list "-DENABLE_MILTER=OFF" "-DENABLE_UNRAR=OFF")
+                 #:outputs outputs)))
+            (replace 'build
+              (assoc-ref cmake:%standard-phases 'build))
+            (add-after 'patch-cargo-checksums 'patch-rust-requirements
+              (lambda _
+                (substitute* "libclamav_rust/Cargo.toml"
+                  (("onenote_parser = .*")
+                   (format #f "onenote_parser = ~s~%"
+                           #$(package-version
+                              (car (assoc-ref cargo-inputs
+                                              "rust-onenote-parser")))))
+                  (("^bindgen = .*")
+                   (format #f "bindgen = ~s~%"
+                           #$(package-version
+                              (car (assoc-ref cargo-inputs
+                                              "rust-bindgen")))))
+                  (("cbindgen = \\{ version =\".*\",")
+                   (format #f "cbindgen = { version =~s,"
+                           #$(package-version
+                              (car (assoc-ref cargo-development-inputs
+                                              "rust-cbindgen"))))))))
+            (delete 'package)
+            (replace 'install
+              (assoc-ref cmake:%standard-phases 'install))
+            (replace 'check
+              (lambda* (#:key tests? #:allow-other-keys)
+                ((assoc-ref cmake:%standard-phases 'check)
+                 #:tests? tests?
+                 #:parallel-tests? #t
+                 #:test-target "test")))
+            (add-after 'unpack 'skip-clamd-tests
+              ;; XXX: The check?_clamd tests fail inside the build
+              ;; chroot, but pass outside.
+              (lambda* (#:key tests? #:allow-other-keys)
+                (when tests?
+                  (substitute* "unit_tests/CMakeLists.txt"
+                    (("clamd_test\\.py" test)
+                     (string-append
+                      test " -k \"not test_clamd_08_VirusEvent\""))))))))))
     (native-inputs
      (list check ; for tests
+           cmake-minimal
            pkg-config
            python-minimal
-           python-pytest
-           rust
-           (list rust "cargo")))
+           python-pytest))
     (inputs
       (list bzip2
             curl
