diff --git a/gnu/packages/python-science.scm b/gnu/packages/python-science.scm
index d076c877fc..a419f4d023 100644
--- a/gnu/packages/python-science.scm
+++ b/gnu/packages/python-science.scm
@@ -754,6 +754,84 @@ (define-public python-xarray-einstats
 functions and around einops with an API and features adapted to xarray.")
     (license license:asl2.0)))
 
+(define-public python-pytensor
+  (package
+    (name "python-pytensor")
+    (version "2.11.3")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url "https://github.com/pymc-devs/pytensor")
+                    (commit (string-append "rel-" version))))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "1qg38jv1244v5lzjgnb116jpz1gj8p3c5pjxr2nvkx7qpjwzxvk6"))))
+    (build-system pyproject-build-system)
+    (arguments
+     (list #:phases #~(modify-phases %standard-phases
+                        (add-after 'unpack 'write-permissions
+                          (lambda _
+                            (setenv "HOME" "/tmp")))
+                        (add-after 'unpack 'versioneer
+                          (lambda _
+                            ;; Our version of versioneer needs setup.cfg.
+                            ;; This is adapted from pyproject.toml.
+                            (with-output-to-file "setup.cfg"
+                              (lambda ()
+                                (display
+                                 "[versioneer]
+VCS = git
+style = pep440
+versionfile_source = pytensor/_version.py
+versionfile_build = pytensor/_version.py
+tag_prefix = rel-
+")))
+                            (invoke "versioneer" "install")
+                            (substitute* "setup.py"
+                              (("versioneer.get_version\\(\\)")
+                               (string-append "\""
+                                              #$version "\"")))))
+                        (replace 'check
+                          (lambda* (#:key tests? #:allow-other-keys)
+                            (when tests?
+                              ;; Test discovery fails, have to call pytest by hand
+                              ;; test_tensor_basic.py file requires JAX.
+                              (invoke "python" "-m" "pytest" "-vv"
+                                      "--ignore"
+                                      "tests/link/jax/test_tensor_basic.py"
+                                      ;; Skip benchmark tests.
+                                      "-k"
+                                      (string-append "not test_elemwise_speed"
+                                       " and not test_logsumexp_benchmark"
+                                       " and not test_fused_elemwise_benchmark"
+                                       " and not test_scan_multiple_output"
+                                       " and not test_vector_taps_benchmark"
+                                       " and not test_cython_performance")
+                                      ;; Skip computationally intensive tests.
+                                      "--ignore" "tests/scan/"
+                                      "--ignore" "tests/tensor/"
+                                      "--ignore" "tests/sandbox/"
+                                      "--ignore" "tests/sparse/sandbox/")))))))
+    (native-inputs (list python-cython python-pytest python-versioneer))
+    (propagated-inputs (list python-cons
+                             python-etuples
+                             python-filelock
+                             python-logical-unification
+                             python-minikanren
+                             python-numba
+                             python-numpy
+                             python-scipy
+                             python-typing-extensions))
+    (home-page "https://pytensor.readthedocs.io/en/latest/")
+    (synopsis
+     "Library for mathematical expressions in multi-dimensional arrays")
+    (description
+     "PyTensor is a Python library that allows one to define,
+optimize, and efficiently evaluate mathematical expressions involving
+multi-dimensional arrays.  It is a fork of the Aesara library.")
+    (license license:bsd-3)))
+
 (define-public python-msgpack-numpy
   (package
     (name "python-msgpack-numpy")
