diff --git a/gnu/local.mk b/gnu/local.mk
index 9bad87710c..702c430623 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1720,6 +1720,7 @@ dist_patch_DATA =						\
   %D%/packages/patches/python-waitress-fix-tests.patch		\
   %D%/packages/patches/python-werkzeug-tests.patch		\
   %D%/packages/patches/python-mypy-12332.patch			\
+  %D%/packages/patches/python-mypy-use-sys-path.patch		\
   %D%/packages/patches/qemu-build-info-manual.patch		\
   %D%/packages/patches/qemu-glibc-2.27.patch 			\
   %D%/packages/patches/qemu-glibc-2.30.patch 			\
diff --git a/gnu/packages/patches/python-mypy-use-sys-path.patch b/gnu/packages/patches/python-mypy-use-sys-path.patch
new file mode 100644
index 0000000000..1b12526456
--- /dev/null
+++ b/gnu/packages/patches/python-mypy-use-sys-path.patch
@@ -0,0 +1,130 @@
+This patch fixes the annotation files search of mypy on non-FHS distributions.
+
+Submitted upstream: https://github.com/python/mypy/pull/12530
+
+diff --git a/mypy/main.py b/mypy/main.py
+index 3d9836587..f9b0cbd39 100644
+--- a/mypy/main.py
++++ b/mypy/main.py
+@@ -1033,10 +1033,10 @@ def process_options(args: List[str],
+     # Set target.
+     if special_opts.modules + special_opts.packages:
+         options.build_type = BuildType.MODULE
+-        egg_dirs, site_packages = get_site_packages_dirs(options.python_executable)
++        site_packages = get_site_packages_dirs(options.python_executable)
+         search_paths = SearchPaths((os.getcwd(),),
+                                    tuple(mypy_path() + options.mypy_path),
+-                                   tuple(egg_dirs + site_packages),
++                                   tuple(site_packages),
+                                    ())
+         targets = []
+         # TODO: use the same cache that the BuildManager will
+diff --git a/mypy/modulefinder.py b/mypy/modulefinder.py
+index 94d2dd34c..337a2d59b 100644
+--- a/mypy/modulefinder.py
++++ b/mypy/modulefinder.py
+@@ -629,7 +629,7 @@ def get_prefixes(python_executable: Optional[str]) -> Tuple[str, str]:
+ 
+ 
+ @functools.lru_cache(maxsize=None)
+-def get_site_packages_dirs(python_executable: Optional[str]) -> Tuple[List[str], List[str]]:
++def get_site_packages_dirs(python_executable: Optional[str]) -> List[str]:
+     """Find package directories for given python.
+ 
+     This runs a subprocess call, which generates a list of the egg directories, and the site
+@@ -648,51 +648,7 @@ def get_site_packages_dirs(python_executable: Optional[str]) -> Tuple[List[str],
+         site_packages = ast.literal_eval(
+             subprocess.check_output([python_executable, pyinfo.__file__, 'getsitepackages'],
+             stderr=subprocess.PIPE).decode())
+-    return expand_site_packages(site_packages)
+-
+-
+-def expand_site_packages(site_packages: List[str]) -> Tuple[List[str], List[str]]:
+-    """Expands .pth imports in site-packages directories"""
+-    egg_dirs: List[str] = []
+-    for dir in site_packages:
+-        if not os.path.isdir(dir):
+-            continue
+-        pth_filenames = sorted(name for name in os.listdir(dir) if name.endswith(".pth"))
+-        for pth_filename in pth_filenames:
+-            egg_dirs.extend(_parse_pth_file(dir, pth_filename))
+-
+-    return egg_dirs, site_packages
+-
+-
+-def _parse_pth_file(dir: str, pth_filename: str) -> Iterator[str]:
+-    """
+-    Mimics a subset of .pth import hook from Lib/site.py
+-    See https://github.com/python/cpython/blob/3.5/Lib/site.py#L146-L185
+-    """
+-
+-    pth_file = os.path.join(dir, pth_filename)
+-    try:
+-        f = open(pth_file, "r")
+-    except OSError:
+-        return
+-    with f:
+-        for line in f.readlines():
+-            if line.startswith("#"):
+-                # Skip comment lines
+-                continue
+-            if line.startswith(("import ", "import\t")):
+-                # import statements in .pth files are not supported
+-                continue
+-
+-            yield _make_abspath(line.rstrip(), dir)
+-
+-
+-def _make_abspath(path: str, root: str) -> str:
+-    """Take a path and make it absolute relative to root if not already absolute."""
+-    if os.path.isabs(path):
+-        return os.path.normpath(path)
+-    else:
+-        return os.path.join(root, os.path.normpath(path))
++    return site_packages
+ 
+ 
+ def add_py2_mypypath_entries(mypypath: List[str]) -> List[str]:
+@@ -781,7 +737,7 @@ def compute_search_paths(sources: List[BuildSource],
+     if options.python_version[0] == 2:
+         mypypath = add_py2_mypypath_entries(mypypath)
+ 
+-    egg_dirs, site_packages = get_site_packages_dirs(options.python_executable)
++    site_packages = get_site_packages_dirs(options.python_executable)
+     base_prefix, prefix = get_prefixes(options.python_executable)
+     is_venv = base_prefix != prefix
+     for site_dir in site_packages:
+@@ -801,7 +757,7 @@ def compute_search_paths(sources: List[BuildSource],
+ 
+     return SearchPaths(python_path=tuple(reversed(python_path)),
+                        mypy_path=tuple(mypypath),
+-                       package_path=tuple(egg_dirs + site_packages),
++                       package_path=tuple(site_packages),
+                        typeshed_path=tuple(lib_path))
+ 
+ 
+diff --git a/mypy/pyinfo.py b/mypy/pyinfo.py
+index ab2d3286b..9fb0501a1 100644
+--- a/mypy/pyinfo.py
++++ b/mypy/pyinfo.py
+@@ -24,16 +24,11 @@ def getprefixes():
+ 
+ def getsitepackages():
+     # type: () -> List[str]
+-    res = []
+-    if hasattr(site, 'getsitepackages'):
+-        res.extend(site.getsitepackages())
+ 
+-        if hasattr(site, 'getusersitepackages') and site.ENABLE_USER_SITE:
+-            res.insert(0, site.getusersitepackages())
+-    else:
+-        from distutils.sysconfig import get_python_lib
+-        res = [get_python_lib()]
+-    return res
++    # Simply return sys.path, which has already been expanded
++    # correctly via Python's site.py module, which takes care of .pth,
++    # sitecustomize.py files, etc.
++    return sys.path
+ 
+ 
+ if __name__ == '__main__':
diff --git a/gnu/packages/python-check.scm b/gnu/packages/python-check.scm
index 2d35eb720e..03895a44c7 100644
--- a/gnu/packages/python-check.scm
+++ b/gnu/packages/python-check.scm
@@ -2,7 +2,7 @@
 ;;; Copyright © 2019, 2021, 2022 Ricardo Wurmus <rekado@elephly.net>
 ;;; Copyright © 2019, 2020 Tobias Geerinckx-Rice <me@tobias.gr>
 ;;; Copyright © 2019, 2020, 2021 Efraim Flashner <efraim@flashner.co.il>
-;;; Copyright © 2019, 2020, 2021 Maxim Cournoyer <maxim.cournoyer@gmail.com>
+;;; Copyright © 2019, 2020, 2021, 2022 Maxim Cournoyer <maxim.cournoyer@gmail.com>
 ;;; Copyright © 2019, 2021 Hartmut Goebel <h.goebel@crazy-compilers.com>
 ;;; Copyright © 2020 Julien Lepiller <julien@lepiller.eu>
 ;;; Copyright © 2020, 2022 Marius Bakke <marius@gnu.org>
@@ -1672,7 +1672,7 @@ (define-public python-mypy-extensions
 (define-public python-mypy
   (package
     (name "python-mypy")
-    (version "0.931")
+    (version "0.942")
     (source
      (origin
        ;; Because of https://github.com/python/mypy/issues/9584, the
@@ -1689,9 +1689,10 @@ (define-public python-mypy
        (file-name (git-file-name name version))
        (sha256
         (base32
-         "1v83flrdxh8grcp40qw04q4hzjflih9xwib64078vsxv2w36f817"))
+         "0hxnrqhvskiclwfj2s4gyfclzjas1dvpfxhyng8v7mq38rqps1j5"))
        (patches
-        (search-patches "python-mypy-12332.patch"))))
+        (search-patches "python-mypy-12332.patch"
+                        "python-mypy-use-sys-path.patch"))))
     (build-system python-build-system)
     (arguments
      `(#:phases
@@ -1713,10 +1714,10 @@ (define-public python-mypy
     (home-page "http://www.mypy-lang.org/")
     (synopsis "Static type checker for Python")
     (description "Mypy is an optional static type checker for Python that aims
-to combine the benefits of dynamic (or 'duck') typing and static typing.  Mypy combines
+to combine the benefits of dynamic typing and static typing.  Mypy combines
 the expressive power and convenience of Python with a powerful type system and
-compile-time type checking.  Mypy type checks standard Python programs; run them using
-any Python VM with basically no runtime overhead.")
+compile-time type checking.  Mypy type checks standard Python programs; run
+them using any Python VM with basically no runtime overhead.")
     ;; Most of the code is under MIT license; Some files are under Python Software
     ;; Foundation License version 2: stdlib-samples/*, mypyc/lib-rt/pythonsupport.h and
     ;; mypyc/lib-rt/getargs.c
