diff --git a/gnu/local.mk b/gnu/local.mk
index cf8849cf598..4bd333e56f2 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1120,6 +1120,7 @@ dist_patch_DATA =						\
   %D%/packages/patches/glibc-hurd-mach-print.patch		\
   %D%/packages/patches/glibc-hurd-magic-pid.patch		\
   %D%/packages/patches/glibc-hurd-signal-sa-siginfo.patch	\
+  %D%/packages/patches/glibc-ldd-powerpc.patch			\
   %D%/packages/patches/glibc-ldd-x86_64.patch			\
   %D%/packages/patches/glibc-locales.patch			\
   %D%/packages/patches/glibc-locales-2.28.patch			\
diff --git a/gnu/packages/base.scm b/gnu/packages/base.scm
index 9aa69cfe773..7c5ac61f01c 100644
--- a/gnu/packages/base.scm
+++ b/gnu/packages/base.scm
@@ -5,7 +5,7 @@
 ;;; Copyright © 2014, 2015, 2016, 2018 Mark H Weaver <mhw@netris.org>
 ;;; Copyright © 2014 Alex Kost <alezost@gmail.com>
 ;;; Copyright © 2014, 2015 Manolis Fragkiskos Ragkousis <manolis837@gmail.com>
-;;; Copyright © 2016, 2017, 2019, 2020 Efraim Flashner <efraim@flashner.co.il>
+;;; Copyright © 2016, 2017, 2019, 2020, 2021 Efraim Flashner <efraim@flashner.co.il>
 ;;; Copyright © 2016, 2020 Jan (janneke) Nieuwenhuizen <janneke@gnu.org>
 ;;; Copyright © 2016, 2018 Alex Vong <alexvong1995@gmail.com>
 ;;; Copyright © 2017 Rene Saavedra <rennes@openmailbox.org>
@@ -15,6 +15,8 @@
 ;;; Copyright © 2018 Tobias Geerinckx-Rice <me@tobias.gr>
 ;;; Copyright © 2018, 2019 Ricardo Wurmus <rekado@elephly.net>
 ;;; Copyright © 2020 Vitaliy Shatrov <D0dyBo0D0dyBo0@protonmail.com>
+;;; Copyright © 2020 Chris Marusich <cmmarusich@gmail.com>
+;;; Copyright © 2021 Leo Le Bouter <lle-bout@zaclys.net>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -890,6 +892,14 @@ the store.")
                                               files)))
                        #t)))
 
+                 ,@(if (target-powerpc?)
+                     '((add-after 'unpack 'apply-patch
+                         (lambda* (#:key inputs #:allow-other-keys)
+                           (let ((patch (assoc-ref inputs
+                                                   "powerpc64le-patch")))
+                             (invoke "patch" "--force" "-p1"
+                                     "-i" patch)))))
+                     '())
                  ,@(if (hurd-target?)
                        '((add-after 'install 'augment-libc.so
                            (lambda* (#:key outputs #:allow-other-keys)
@@ -911,6 +921,10 @@ the store.")
                     ("gettext" ,gettext-minimal)
                     ("python" ,python-minimal)
 
+                    ,@(if (target-powerpc?)
+                        `(("powerpc64le-patch" ,@(search-patches
+                                                   "glibc-ldd-powerpc.patch")))
+                        '())
                     ,@(if (hurd-target?)
                           `(("mig" ,mig)
                             ("perl" ,perl))
diff --git a/gnu/packages/commencement.scm b/gnu/packages/commencement.scm
index 432910d7a30..93b0c508822 100644
--- a/gnu/packages/commencement.scm
+++ b/gnu/packages/commencement.scm
@@ -3313,7 +3313,11 @@ memoized as a function of '%current-system'."
      `(("bison" ,bison-boot0)
        ("texinfo" ,texinfo-boot0)
        ("perl" ,perl-boot0)
-       ("python" ,python-boot0)))
+       ("python" ,python-boot0)
+       ,@(if (target-powerpc?)
+           `(("powerpc64le-patch" ,@(search-patches
+                                      "glibc-ldd-powerpc.patch")))
+           '())))
     (inputs
      `( ;; The boot inputs.  That includes the bootstrap libc.  We don't want
        ;; it in $CPATH, hence the 'pre-configure' phase above.
@@ -3464,6 +3468,10 @@ exec ~a/bin/~a-~a -B~a/lib -Wl,-dynamic-linker -Wl,~a/~a \"$@\"~%"
 
    ;; This time we need 'msgfmt' to install all the libc.mo files.
    (native-inputs `(,@(package-native-inputs glibc-final-with-bootstrap-bash)
+                     ,@(if (target-powerpc?)
+                         `(("powerpc64le-patch" ,@(search-patches
+                                                    "glibc-ldd-powerpc.patch")))
+                         '())
                     ("gettext" ,gettext-boot0)))
 
    (propagated-inputs
diff --git a/gnu/packages/patches/glibc-ldd-powerpc.patch b/gnu/packages/patches/glibc-ldd-powerpc.patch
new file mode 100644
index 00000000000..8e899ee99b8
--- /dev/null
+++ b/gnu/packages/patches/glibc-ldd-powerpc.patch
@@ -0,0 +1,10 @@
+diff -r -U3 a/sysdeps/unix/sysv/linux/powerpc/ldd-rewrite.sed b/sysdeps/unix/sysv/linux/powerpc/ldd-rewrite.sed
+--- a/sysdeps/unix/sysv/linux/powerpc/ldd-rewrite.sed	1970-01-01 01:00:00.000000000 +0100
++++ b/sysdeps/unix/sysv/linux/powerpc/ldd-rewrite.sed	2020-02-29 00:15:41.080000000 +0100
+@@ -11,5 +11,5 @@
+ # this works for /lib64/ld64.so.x and /lib/ld.so.x as input
+ s_lib64_lib_
+ s_64\.so_\.so_
+-s_^RTLDLIST=\(.*lib\)\(/[^/]*\)\(\.so\.[0-9.]*\)[[:blank:]]*$_RTLDLIST="\1\2\3 \164\264\3"_
++s_^RTLDLIST=\(.*lib\)\(/[^/]*\)\(\.so\.[0-9.]*\)[[:blank:]]*$_RTLDLIST="\1\2\3 \1\264\3"_
+ 
