diff --git a/Makefile.am b/Makefile.am
index f40d9509bee..1c2d45527c7 100644
--- a/Makefile.am
+++ b/Makefile.am
@@ -14,6 +14,7 @@
 # Copyright © 2018 Oleg Pykhalov <go.wigust@gmail.com>
 # Copyright © 2018 Alex Vong <alexvong1995@gmail.com>
 # Copyright © 2019 Efraim Flashner <efraim@flashner.co.il>
+# Copyright © 2021 Chris Marusich <cmmarusich@gmail.com>
 #
 # This file is part of GNU Guix.
 #
@@ -799,7 +800,8 @@ SOURCE_TARBALLS =					\
   $(foreach ext,tar.gz,$(PACKAGE_FULL_TARNAME).$(ext))
 
 # Systems supported by Guix.
-SUPPORTED_SYSTEMS ?= x86_64-linux i686-linux armhf-linux aarch64-linux
+SUPPORTED_SYSTEMS ?= x86_64-linux i686-linux armhf-linux aarch64-linux \
+  powerpc64le-linux
 
 # Guix binary tarballs.
 BINARY_TARBALLS =							\
diff --git a/etc/guix-install.sh b/etc/guix-install.sh
index 94c04aa646a..c84e7b75779 100755
--- a/etc/guix-install.sh
+++ b/etc/guix-install.sh
@@ -8,6 +8,7 @@
 # Copyright © 2020 Simon Tournier <zimon.toutoune@gmail.com>
 # Copyright © 2020 Daniel Brooks <db48x@db48x.net>
 # Copyright © 2021 Jakub Kądziołka <kuba@kadziolka.net>
+# Copyright © 2021 Chris Marusich <cmmarusich@gmail.com>
 #
 # This file is part of GNU Guix.
 #
@@ -187,6 +188,9 @@ chk_sys_arch()
         armv7l)
             local arch=armhf
             ;;
+        ppc64le | powerpc64le)
+            local arch=powerpc64le
+            ;;
         *)
             _err "${ERR}Unsupported CPU type: ${arch}"
             exit 1
diff --git a/guix/packages.scm b/guix/packages.scm
index a057a88c638..55e5e70b8c6 100644
--- a/guix/packages.scm
+++ b/guix/packages.scm
@@ -5,6 +5,7 @@
 ;;; Copyright © 2016 Alex Kost <alezost@gmail.com>
 ;;; Copyright © 2017, 2019, 2020 Efraim Flashner <efraim@flashner.co.il>
 ;;; Copyright © 2019 Marius Bakke <mbakke@fastmail.com>
+;;; Copyright © 2021 Chris Marusich <cmmarusich@gmail.com>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -345,7 +346,8 @@ name of its URI."
 (define %supported-systems
   ;; This is the list of system types that are supported.  By default, we
   ;; expect all packages to build successfully here.
-  '("x86_64-linux" "i686-linux" "armhf-linux" "aarch64-linux" "mips64el-linux" "i586-gnu"))
+  '("x86_64-linux" "i686-linux" "armhf-linux" "aarch64-linux" "mips64el-linux" "i586-gnu"
+    "powerpc64le-linux"))
 
 (define %hurd-systems
   ;; The GNU/Hurd systems for which support is being developed.
diff --git a/m4/guix.m4 b/m4/guix.m4
index c1ce0876fa0..f0d85a28d6d 100644
--- a/m4/guix.m4
+++ b/m4/guix.m4
@@ -2,6 +2,7 @@ dnl GNU Guix --- Functional package management for GNU
 dnl Copyright © 2012, 2013, 2014, 2015, 2016, 2018, 2019, 2020, 2021 Ludovic Courtès <ludo@gnu.org>
 dnl Copyright © 2014 Mark H Weaver <mhw@netris.org>
 dnl Copyright © 2017 Efraim Flashner <efraim@flashner.co.il>
+dnl Copyright © 2021 Chris Marusich <cmmarusich@gmail.com>
 dnl
 dnl This file is part of GNU Guix.
 dnl
@@ -88,7 +89,7 @@ courageous and port the GNU System distribution to it (see
   # Currently only Linux-based systems are supported, and only on some
   # platforms.
   case "$guix_system" in
-    x86_64-linux|i686-linux|armhf-linux|aarch64-linux)
+    x86_64-linux|i686-linux|armhf-linux|aarch64-linux|powerpc64le-linux)
       ;;
     *)
       if test "x$guix_courageous" = "xyes"; then
diff --git a/tests/guix-build.sh b/tests/guix-build.sh
index b7602e668c4..e20702c521b 100644
--- a/tests/guix-build.sh
+++ b/tests/guix-build.sh
@@ -1,6 +1,7 @@
 # GNU Guix --- Functional package management for GNU
 # Copyright © 2012, 2013, 2014, 2016, 2017, 2018, 2019, 2020 Ludovic Courtès <ludo@gnu.org>
 # Copyright © 2020 Marius Bakke <mbakke@fastmail.com>
+# Copyright © 2021 Chris Marusich <cmmarusich@gmail.com>
 #
 # This file is part of GNU Guix.
 #
@@ -61,8 +62,9 @@ guix build -e '(@@ (gnu packages bootstrap) %bootstrap-guile)'
 test `guix build sed -s x86_64-linux -d | wc -l` = 1
 
 # Passing multiple '-s' flags.
-all_systems="-s x86_64-linux -s i686-linux -s armhf-linux -s aarch64-linux"
-test `guix build sed $all_systems -d | sort -u | wc -l` = 4
+all_systems="-s x86_64-linux -s i686-linux -s armhf-linux -s aarch64-linux \
+-s powerpc64le-linux"
+test `guix build sed $all_systems -d | sort -u | wc -l` = 5
 
 # Check there's no weird memoization effect leading to erroneous results.
 # See <https://bugs.gnu.org/40482>.
