diff --git a/gnu/packages/ebook.scm b/gnu/packages/ebook.scm
index 763e3eba2b..124fcda4df 100644
--- a/gnu/packages/ebook.scm
+++ b/gnu/packages/ebook.scm
@@ -2,7 +2,7 @@
 ;;; Copyright © 2015, 2016 Andreas Enge <andreas@enge.fr>
 ;;; Copyright © 2016, 2018 Efraim Flashner <efraim@flashner.co.il>
 ;;; Copyright © 2016, 2017 Alex Griffin <a@ajgrf.com>
-;;; Copyright © 2017, 2019, 2020 Brendan Tildesley <mail@brendan.scot>
+;;; Copyright © 2017, 2019, 2020, 2021 Brendan Tildesley <mail@brendan.scot>
 ;;; Copyright © 2017 Roel Janssen <roel@gnu.org>
 ;;; Copyright © 2018, 2019, 2020 Tobias Geerinckx-Rice <me@tobias.gr>
 ;;; Copyright © 2020 Marius Bakke <mbakke@fastmail.com>
@@ -58,10 +58,14 @@
   #:use-module (gnu packages pdf)
   #:use-module (gnu packages pkg-config)
   #:use-module (gnu packages python)
+  #:use-module (gnu packages python-build)
+  #:use-module (gnu packages python-compression)
+  #:use-module (gnu packages python-crypto)
   #:use-module (gnu packages python-web)
   #:use-module (gnu packages python-xyz)
   #:use-module (gnu packages qt)
   #:use-module (gnu packages serialization)
+  #:use-module (gnu packages speech)
   #:use-module (gnu packages sqlite)
   #:use-module (gnu packages time)
   #:use-module (gnu packages tls)
@@ -111,7 +115,7 @@
 (define-public calibre
   (package
     (name "calibre")
-    (version "4.18.0")
+    (version "5.13.0")
     (source
       (origin
         (method url-fetch)
@@ -120,7 +124,7 @@
                             version ".tar.xz"))
         (sha256
          (base32
-          "0w9pcfvskjh4v00vjw3i6hzrafy863pgsmmqdx4lffip3p856brw"))
+          "08sljr5rg5f5i1s92g2li5f63mw458b8w5drgcxjm4k62rkl0c8q"))
         (modules '((guix build utils)))
         (snippet
           '(begin
@@ -145,17 +149,16 @@
     (native-inputs
      `(("pkg-config" ,pkg-config)
        ("qtbase" ,qtbase) ; for qmake
-       ("python2-flake8" ,python2-flake8)
+       ("python-flake8" ,python-flake8)
+       ("python-pyqt-builder" ,python-pyqt-builder)
        ("xdg-utils" ,xdg-utils)))
     (inputs
-     `(("chmlib" ,chmlib)
-       ("fontconfig" ,fontconfig)
+     `(("fontconfig" ,fontconfig)
        ("font-liberation" ,font-liberation)
        ("glib" ,glib)
        ("hunspell" ,hunspell)
        ("hyphen" ,hyphen)
        ("icu4c" ,icu4c)
-       ("js-mathjax" ,js-mathjax)
        ("libmtp" ,libmtp)
        ("libpng" ,libpng)
        ("libusb" ,libusb)
@@ -163,39 +166,41 @@
        ("optipng" ,optipng)
        ("podofo" ,podofo)
        ("poppler" ,poppler)
-       ("python" ,python-2)
-       ("python2-apsw" ,python2-apsw)
-       ("python2-beautifulsoup4" ,python2-beautifulsoup4)
-       ("python2-chardet" ,python2-chardet)
-       ("python2-cssselect" ,python2-cssselect)
-       ("python2-css-parser" ,python2-css-parser)
-       ("python2-dateutil" ,python2-dateutil)
-       ("python2-dbus" ,python2-dbus)
-       ("python2-dnspython" ,python2-dnspython-1.16)
-       ("python2-dukpy" ,python2-dukpy)
-       ("python2-feedparser" ,python2-feedparser)
-       ("python2-html2text" ,python2-html2text)
-       ("python2-html5-parser" ,python2-html5-parser)
-       ("python2-html5lib" ,python2-html5lib)
-       ("python2-lxml" ,python2-lxml)
-       ("python2-markdown" ,python2-markdown)
-       ("python2-mechanize" ,python2-mechanize)
-       ;; python2-msgpack is needed for the network content server to work.
-       ("python2-msgpack" ,python2-msgpack)
-       ("python2-netifaces" ,python2-netifaces)
-       ("python2-odfpy" ,python2-odfpy)
-       ("python2-pillow" ,python2-pillow)
-       ("python2-psutil" ,python2-psutil)
-       ("python2-pygments" ,python2-pygments)
-       ("python2-pyqtwebengine" ,python2-pyqtwebengine)
-       ("python2-pyqt" ,python2-pyqt)
-       ("python2-sip" ,python2-sip)
-       ("python2-regex" ,python2-regex)
+       ("python-apsw" ,python-apsw)
+       ("python-beautifulsoup4" ,python-beautifulsoup4)
+       ("python-cchardet" ,python-cchardet)
+       ("python-css-parser" ,python-css-parser)
+       ("python-cssselect" ,python-cssselect)
+       ("python-dateutil" ,python-dateutil)
+       ("python-dbus" ,python-dbus)
+       ("python-dnspython" ,python-dnspython-1.16)
+       ("python-dukpy" ,python-dukpy)
+       ("python-feedparser" ,python-feedparser)
+       ("python-html2text" ,python-html2text)
+       ("python-html5-parser" ,python-html5-parser)
+       ("python-html5lib" ,python-html5lib)
+       ("python-lxml" ,python-lxml)
+       ("python-markdown" ,python-markdown)
+       ("python-mechanize" ,python-mechanize)
+       ;; python-msgpack is needed for the network content server to work.
+       ("python-msgpack" ,python-msgpack)
+       ("python-netifaces" ,python-netifaces)
+       ("python-odfpy" ,python-odfpy)
+       ("python-pillow" ,python-pillow)
+       ("python-psutil" ,python-psutil)
+       ("python-py7zr" ,python-py7zr)
+       ("python-pychm" ,python-pychm)
+       ("python-pycryptodome" ,python-pycryptodome)
+       ("python-pygments" ,python-pygments)
+       ("python-pyqt" ,python-pyqt)
+       ("python-pyqtwebengine" ,python-pyqtwebengine)
+       ("python-regex" ,python-regex)
+       ("python-speechd" ,speech-dispatcher)
+       ("python-zeroconf" ,python-zeroconf)
        ("qtwebengine" ,qtwebengine)
        ("sqlite" ,sqlite)))
     (arguments
-     `(#:python ,python-2
-       ;; Calibre is using setuptools by itself, but the setup.py is not
+     `(;; Calibre is using setuptools by itself, but the setup.py is not
        ;; compatible with the shim wrapper (taken from pip) we are using.
        #:use-setuptools? #f
        #:phases
@@ -227,13 +232,16 @@
          (add-before 'build 'configure
           (lambda* (#:key inputs outputs #:allow-other-keys)
             (let ((podofo (assoc-ref inputs "podofo"))
-                  (pyqt (assoc-ref inputs "python2-pyqt"))
-                  (python-sip (assoc-ref inputs "python2-sip"))
+                  (pyqt (assoc-ref inputs "python-pyqt"))
+                  (python-sip (assoc-ref inputs "python-sip"))
                   (out (assoc-ref outputs "out")))
-              (substitute* "setup/build_environment.py"
-                (("= get_sip_dir\\(\\)")
-                 (string-append "= '" pyqt "/share/sip'")))
-
+              (substitute* "setup/build.py"
+                (("\\[tool.sip.bindings.pictureflow\\]")
+                 "[tool.sip.bindings.pictureflow]
+tags = [\"WS_X11\"]")
+                (("\\[tool.sip.project\\]")
+                 (string-append "[tool.sip.project]
+sip-include-dirs = [\"" pyqt "/share/sip" "\"]")))
               (substitute* "src/calibre/ebooks/pdf/pdftohtml.py"
                 (("PDFTOHTML = 'pdftohtml'")
                  (string-append "PDFTOHTML = \"" (assoc-ref inputs "poppler")
@@ -257,7 +265,6 @@
                                       "/share/fonts")
                        "/tmp/.fonts")
 
-              (setenv "SIP_BIN" (string-append python-sip "/bin/sip"))
               (setenv "PODOFO_INC_DIR" (string-append podofo "/include/podofo"))
               (setenv "PODOFO_LIB_DIR" (string-append podofo "/lib"))
               ;; This informs the tests we are a continuous integration
@@ -270,11 +277,7 @@
               #t)))
          (add-after 'build 'build-extra
            (lambda* (#:key inputs #:allow-other-keys)
-             (invoke "python2" "setup.py" "mathjax""--system-mathjax"
-                     "--path-to-mathjax" (string-append
-                                          (assoc-ref inputs "js-mathjax")
-                                          "/share/javascript/mathjax"))
-             (invoke "python2" "setup.py" "rapydscript")
+             (invoke "python" "setup.py" "rapydscript")
              #t))
          (add-after 'install 'install-man-pages
            (lambda* (#:key outputs #:allow-other-keys)
diff --git a/gnu/packages/patches/calibre-no-updates-dialog.patch b/gnu/packages/patches/calibre-no-updates-dialog.patch
index 1d8d79660e..66ac913cb5 100644
--- a/gnu/packages/patches/calibre-no-updates-dialog.patch
+++ b/gnu/packages/patches/calibre-no-updates-dialog.patch
@@ -1,11 +1,17 @@
-Taken from debian.
+From 19e8d7701c302b0eca4c638705a6db625352caa3 Mon Sep 17 00:00:00 2001
+From: Brendan Tildesley <mail@brendan.scot>
+Date: Thu, 25 Feb 2021 12:17:30 +1100
+Subject: [PATCH] Don't check for updates.
 
-# Description: Disable update check by default.
-Index: calibre/src/calibre/gui2/main.py
-===================================================================
---- calibre.orig/src/calibre/gui2/main.py	2014-02-02 10:41:28.470954623 +0100
-+++ calibre/src/calibre/gui2/main.py	2014-02-02 10:41:56.546954247 +0100
-@@ -37,8 +37,8 @@
+---
+ src/calibre/gui2/main.py | 4 ++--
+ 1 file changed, 2 insertions(+), 2 deletions(-)
+
+diff --git a/src/calibre/gui2/main.py b/src/calibre/gui2/main.py
+index 776f8bebfb..4302716d7e 100644
+--- a/src/calibre/gui2/main.py
++++ b/src/calibre/gui2/main.py
+@@ -59,8 +59,8 @@ def option_parser():
                        help=_('Start minimized to system tray.'))
      parser.add_option('-v', '--verbose', default=0, action='count',
                        help=_('Ignored, do not use. Present only for legacy reasons'))
@@ -16,3 +22,5 @@ Index: calibre/src/calibre/gui2/main.py
      parser.add_option('--ignore-plugins', default=False, action='store_true',
              help=_('Ignore custom plugins, useful if you installed a plugin'
                  ' that is preventing calibre from starting'))
+--
+2.30.1
diff --git a/gnu/packages/patches/calibre-remove-test-sqlite.patch b/gnu/packages/patches/calibre-remove-test-sqlite.patch
index 7bdd90874d..fc2b237ef2 100644
--- a/gnu/packages/patches/calibre-remove-test-sqlite.patch
+++ b/gnu/packages/patches/calibre-remove-test-sqlite.patch
@@ -1,20 +1,20 @@
-From a92e26359bd07743ab105819ed0b619e27e14017 Mon Sep 17 00:00:00 2001
+From d8225e83c3b73f0e0da73874910f50ca652f48cf Mon Sep 17 00:00:00 2001
 From: Brendan Tildesley <mail@brendan.scot>
-Date: Sat, 27 Apr 2019 03:30:53 +1000
-Subject: [PATCH] Disable test_sqlite.
+Date: Thu, 25 Feb 2021 00:48:00 +1100
+Subject: [PATCH] Remove test_sqlite
 
 ---
  src/calibre/test_build.py | 6 ------
  1 file changed, 6 deletions(-)
 
 diff --git a/src/calibre/test_build.py b/src/calibre/test_build.py
-index 07bdffd3e5..740588c95b 100644
+index 0ab7aa0646..87fdfabd9a 100644
 --- a/src/calibre/test_build.py
 +++ b/src/calibre/test_build.py
-@@ -162,12 +162,6 @@ class BuildTest(unittest.TestCase):
-             au(x, 'strftime')
-             self.assertEqual(unicode_type(time.strftime(fmt.replace('%e', '%#d'), t)), x)
- 
+@@ -273,12 +273,6 @@ def read_changes():
+         m.close()
+         self.assertEqual(winutil.parse_cmdline('"c:\\test exe.exe" "some arg" 2'), ('c:\\test exe.exe', 'some arg', '2'))
+
 -    def test_sqlite(self):
 -        import sqlite3
 -        conn = sqlite3.connect(':memory:')
@@ -24,6 +24,5 @@ index 07bdffd3e5..740588c95b 100644
      def test_apsw(self):
          import apsw
          conn = apsw.Connection(':memory:')
--- 
-2.21.0
-
+--
+2.30.1
diff --git a/gnu/packages/patches/calibre-remove-test-unrar.patch b/gnu/packages/patches/calibre-remove-test-unrar.patch
index 4e5572d1a6..961cc3eba7 100644
--- a/gnu/packages/patches/calibre-remove-test-unrar.patch
+++ b/gnu/packages/patches/calibre-remove-test-unrar.patch
@@ -1,28 +1,26 @@
-Unrar contains security vulnerabilities and has thus been removed from Guix.
-From a16f97b02bd8afd0ec05c471e156f631f2cc6eec Mon Sep 17 00:00:00 2001
+From 9edf67191cc3655480b6fd418247709ade930b1a Mon Sep 17 00:00:00 2001
 From: Brendan Tildesley <mail@brendan.scot>
-Date: Tue, 26 Mar 2019 22:17:03 +1100
-Subject: [PATCH] Remove test_unrar.
+Date: Thu, 25 Feb 2021 00:33:10 +1100
+Subject: [PATCH] Remove test_unrar
 
 ---
  src/calibre/test_build.py | 4 ----
  1 file changed, 4 deletions(-)
 
 diff --git a/src/calibre/test_build.py b/src/calibre/test_build.py
-index d67afd20a6..709132ef17 100644
+index b37fb1bcfb..0ab7aa0646 100644
 --- a/src/calibre/test_build.py
 +++ b/src/calibre/test_build.py
-@@ -220,10 +220,6 @@ class BuildTest(unittest.TestCase):
+@@ -369,10 +369,6 @@ def test_file_dialog_helper(self):
          from calibre.gui2.win_file_dialogs import test
          test()
- 
+
 -    def test_unrar(self):
 -        from calibre.utils.unrar import test_basic
 -        test_basic()
 -
-     @unittest.skipUnless(iswindows, 'WPD is windows only')
-     def test_wpd(self):
-         wpd = plugins['wpd'][0]
--- 
-2.21.0
-
+     def test_7z(self):
+         from calibre.utils.seven_zip import test_basic
+         test_basic()
+--
+2.30.1
