diff --git a/gnu/local.mk b/gnu/local.mk
index ae708248e8..278879334c 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1065,9 +1065,6 @@ dist_patch_DATA =						\
   %D%/packages/patches/gnupg-default-pinentry.patch		\
   %D%/packages/patches/gnutls-skip-trust-store-test.patch	\
   %D%/packages/patches/gnutls-cross.patch			\
-  %D%/packages/patches/gobject-introspection-absolute-shlib-path.patch \
-  %D%/packages/patches/gobject-introspection-cc.patch		\
-  %D%/packages/patches/gobject-introspection-girepository.patch	\
   %D%/packages/patches/go-skip-gc-test.patch			\
   %D%/packages/patches/gpm-glibc-2.26.patch			\
   %D%/packages/patches/gpsbabel-minizip.patch     		\
diff --git a/gnu/packages/glib.scm b/gnu/packages/glib.scm
index 55ffdf724e..c4bf47512b 100644
--- a/gnu/packages/glib.scm
+++ b/gnu/packages/glib.scm
@@ -330,56 +330,47 @@ threads, dynamic loading, and an object system.")
 (define gobject-introspection
   (package
     (name "gobject-introspection")
-    (version "1.62.0")
-    (source (origin
-             (method url-fetch)
-             (uri (string-append "mirror://gnome/sources/"
-                   "gobject-introspection/" (version-major+minor version)
-                   "/gobject-introspection-" version ".tar.xz"))
-             (sha256
-              (base32 "18lhglg9v6y83lhqzyifc1z0wrlawzrhzzxx0a3h1g7xaz97xvmi"))
-             (patches (search-patches
-                       "gobject-introspection-cc.patch"
-                       "gobject-introspection-girepository.patch"
-                       "gobject-introspection-absolute-shlib-path.patch"))))
+    (version "1.64.1")
+    (source
+     (origin
+       (method url-fetch)
+       (uri
+        (string-append "mirror://gnome/sources/"
+                       name "/" (version-major+minor version) "/"
+                       name "-" version ".tar.xz"))
+       (sha256
+        (base32 "19vz7vp10h0zj3f491yk72dp89bix6rgkzxg4qcm4d6151ksxgl0"))))
     (build-system meson-build-system)
     (arguments
-     `(#:phases
-       (modify-phases %standard-phases
-         (add-after 'unpack 'do-not-use-/usr/bin/env
-           (lambda _
-             (substitute* "tools/g-ir-tool-template.in"
-               (("#!@PYTHON_CMD@")
-                (string-append "#!" (which "python3"))))
-             #t)))))
-    (inputs
+     `(#:glib-or-gtk? #t))   ; To wrap binaries and/or compile schemas
+    (native-inputs
      `(("bison" ,bison)
        ("flex" ,flex)
-       ("glib" ,glib)
-       ("python" ,python-wrapper)
-       ("zlib" ,zlib)))
-    (native-inputs
-     `(("glib" ,glib "bin")
+       ("glib" ,glib "bin")
        ("pkg-config" ,pkg-config)))
+    (inputs
+     `(("glib" ,glib)
+       ("python" ,python-wrapper)))
     (propagated-inputs
-     `(;; In practice, GIR users will need libffi when using
-       ;; gobject-introspection.
-       ("libffi" ,libffi)))
+     `(("libffi" ,libffi)))
     (native-search-paths
      (list (search-path-specification
             (variable "GI_TYPELIB_PATH")
             (files '("lib/girepository-1.0")))))
     (search-paths native-search-paths)
-    (home-page "https://wiki.gnome.org/GObjectIntrospection")
-    (synopsis "Generate interface introspection data for GObject libraries")
-    (description
-     "GObject introspection is a middleware layer between C libraries (using
-GObject) and language bindings.  The C library can be scanned at compile time
-and generate a metadata file, in addition to the actual native C library.  Then
-at runtime, language bindings can read this metadata and automatically provide
-bindings to call into the C library.")
-    ; Some bits are distributed under the LGPL2+, others under the GPL2+
-    (license license:gpl2+)))
+    (synopsis "GObject introspection tools and libraries")
+    (description "GObject introspection is a middleware layer between
+C libraries (using GObject) and language bindings.  The C library can be scanned
+at compile time and generate metadata files, in addition to the actual native
+C library.  Then language bindings can read this metadata and automatically
+provide bindings to call into the C library.")
+    (home-page "https://wiki.gnome.org/Projects/GObjectIntrospection")
+    (license
+     (list
+      ;; For library.
+      license:lgpl2.0+
+      ;; For tools.
+      license:gpl2+))))
 
 (define intltool
   (package
diff --git a/gnu/packages/patches/gobject-introspection-absolute-shlib-path.patch b/gnu/packages/patches/gobject-introspection-absolute-shlib-path.patch
deleted file mode 100644
index 956fa617c3..0000000000
--- a/gnu/packages/patches/gobject-introspection-absolute-shlib-path.patch
+++ /dev/null
@@ -1,166 +0,0 @@
-# Names of libraries included in typelib files are opened by dlopen.  Here we 
-# add the full path.
-#
-# This patch was provided by Luca Bruno <lucabru@src.gnome.org>  for 
-# 'gobject-introspection' 1.40.0 in Nix.
-#
-# It has since been updated to work with newer versions of
-# gobject-introspection.
---- a/giscanner/scannermain.py
-+++ b/giscanner/scannermain.py
-@@ -95,6 +95,39 @@ def get_windows_option_group(parser):
-     return group
- 
- 
-+def _get_default_fallback_libpath():
-+    # Newer multiple-output-optimized stdenv has an environment variable
-+    # $outputLib which in turn specifies another variable which then is used as
-+    # the destination for the library contents (${!outputLib}/lib).
-+    store_path = os.environ.get(os.environ.get("outputLib")) if "outputLib" in os.environ else None
-+    if store_path is None:
-+        outputs = os.environ.get("outputs", "out").split()
-+        if "lib" in outputs:
-+            # For multiple output derivations let's try whether there is a $lib
-+            # environment variable and use that as the base store path.
-+            store_path = os.environ.get("lib")
-+        elif "out" in outputs:
-+            # Otherwise we have a single output derivation, so the libraries
-+            # most certainly will end up in "$out/lib".
-+            store_path = os.environ.get("out")
-+
-+    if store_path is not None:
-+        # Even if we have a $lib as output, there still should be a $lib/lib
-+        # directory.
-+        return os.path.join(store_path, 'lib')
-+    else:
-+        # If we haven't found a possible scenario, let's return an empty string
-+        # so that the shared library won't be prepended with a path.
-+        #
-+        # Note that this doesn't mean that all hope is lost, because after all
-+        # we can still use --fallback-library-path to set one.
-+        #
-+        # Also, we're not returning None, because that would make it very
-+        # difficult to disable adding fallback paths altogether using something
-+        # like: --fallback-library-path=""
-+        return ""
-+
-+
- def _get_option_parser():
-     parser = optparse.OptionParser('%prog [options] sources',
-                                    version='%prog ' + giscanner.__version__)
-@@ -205,6 +238,10 @@ match the namespace prefix.""")
-     parser.add_option("", "--filelist",
-                       action="store", dest="filelist", default=[],
-                       help="file containing headers and sources to be scanned")
-+    parser.add_option("", "--fallback-library-path",
-+                      action="store", dest="fallback_libpath",
-+                      default=_get_default_fallback_libpath(),
-+                      help="Path to prepend to unknown shared libraries")
- 
-     group = get_preprocessor_option_group(parser)
-     parser.add_option_group(group)
---- a/giscanner/shlibs.py
-+++ b/giscanner/shlibs.py
-@@ -57,6 +57,14 @@ def _ldd_library_pattern(library_name):
-     $""" % re.escape(library_name), re.VERBOSE)
- 
- 
-+def _ldd_library_guix_pattern(library_name):
-+    store_dir = re.escape(
-+      os.environ.get("NIX_STORE", default="/gnu/store")
-+    )
-+    pattern = r'(%s(?:/[^/]*)+lib%s[^A-Za-z0-9_-][^\s\(\)]*)'
-+    return re.compile(pattern % (store_dir, re.escape(library_name)))
-+
-+
- # This is a what we do for non-la files. We assume that we are on an
- # ELF-like system where ldd exists and the soname extracted with ldd is
- # a filename that can be opened with dlopen().
-@@ -106,7 +112,8 @@ def _resolve_non_libtool(options, binary, libraries):
-             output = output.decode("utf-8", "replace")
- 
-         shlibs = resolve_from_ldd_output(libraries, output)
--        return list(map(sanitize_shlib_path, shlibs))
-+        fallback_libpath = options.fallback_libpath or "";
-+        return list(map(lambda p: os.path.join(fallback_libpath, p), map(sanitize_shlib_path, shlibs)))
- 
- 
- def sanitize_shlib_path(lib):
-@@ -115,19 +122,18 @@ def sanitize_shlib_path(lib):
-     # In case we get relative paths on macOS (like @rpath) then we fall
-     # back to the basename as well:
-     # https://gitlab.gnome.org/GNOME/gobject-introspection/issues/222
--    if sys.platform == "darwin":
--        if not os.path.isabs(lib):
--            return os.path.basename(lib)
--        return lib
--    else:
-+
-+    # Always use absolute paths if available
-+    if not os.path.isabs(lib):
-         return os.path.basename(lib)
-+    return lib
- 
- 
- def resolve_from_ldd_output(libraries, output):
-     patterns = {}
-     for library in libraries:
-         if not os.path.isfile(library):
--            patterns[library] = _ldd_library_pattern(library)
-+            patterns[library] = (_ldd_library_pattern(library), _ldd_library_guix_pattern(library))
-     if len(patterns) == 0:
-         return []
- 
-@@ -139,8 +145,12 @@ def resolve_from_ldd_output(libraries, output):
-         if line.endswith(':'):
-             continue
-         for word in line.split():
--            for library, pattern in patterns.items():
--                m = pattern.match(word)
-+            for library, (pattern, guix_pattern) in patterns.items():
-+                store_dir = os.environ.get("NIX_STORE", default="/gnu/store")
-+                if line.find(store_dir) != -1:
-+                    m = guix_pattern.match(word)
-+                else:
-+                    m = pattern.match(word)
-                 if m:
-                     del patterns[library]
-                     shlibs.append(m.group())
-
---- a/giscanner/utils.py
-+++ b/giscanner/utils.py
-@@ -111,17 +111,11 @@ def extract_libtool_shlib(la_file):
-     if dlname is None:
-         return None
- 
--    # Darwin uses absolute paths where possible; since the libtool files never
--    # contain absolute paths, use the libdir field
--    if platform.system() == 'Darwin':
--        dlbasename = os.path.basename(dlname)
--        libdir = _extract_libdir_field(la_file)
--        if libdir is None:
--            return dlbasename
--        return libdir + '/' + dlbasename
--    # From the comments in extract_libtool(), older libtools had
--    # a path rather than the raw dlname
--    return os.path.basename(dlname)
-+    dlbasename = os.path.basename(dlname)
-+    libdir = _extract_libdir_field(la_file)
-+    if libdir is None:
-+        return dlbasename
-+    return libdir + '/' + dlbasename
- 
- 
- def extract_libtool(la_file):
---- a/tests/scanner/test_shlibs.py
-+++ b/tests/scanner/test_shlibs.py
-@@ -40,6 +64,7 @@ class TestLddParser(unittest.TestCase):
- 
-         self.assertEqual(
-             sanitize_shlib_path('/foo/bar'),
--            '/foo/bar' if sys.platform == 'darwin' else 'bar')
-+            # Always use an absolute filename for Guix
-+            '/foo/bar')
- 
-     def test_unresolved_library(self):
-output = ''
diff --git a/gnu/packages/patches/gobject-introspection-cc.patch b/gnu/packages/patches/gobject-introspection-cc.patch
deleted file mode 100644
index 6a86b56b44..0000000000
--- a/gnu/packages/patches/gobject-introspection-cc.patch
+++ /dev/null
@@ -1,14 +0,0 @@
-Use gcc as the default C compiler if CC is not set.
-
-diff -ru gobject-introspection-1.58.1.orig/giscanner/__init__.py gobject-introspection-1.58.1/giscanner/__init__.py
---- gobject-introspection-1.58.1.orig/giscanner/__init__.py	1970-01-01 01:00:00.000000000 +0100
-+++ gobject-introspection-1.58.1/giscanner/__init__.py	2018-12-03 13:33:28.788971299 +0100
-@@ -22,6 +22,8 @@
- builddir = os.environ.get('UNINSTALLED_INTROSPECTION_BUILDDIR')
- if builddir is not None:
-     __path__.append(os.path.join(builddir, 'giscanner'))
-+if not 'CC' in os.environ:
-+    os.environ['CC'] = 'gcc'
- try:
-     from ._version import __version__
- except ImportError:
diff --git a/gnu/packages/patches/gobject-introspection-girepository.patch b/gnu/packages/patches/gobject-introspection-girepository.patch
deleted file mode 100644
index 380617f27f..0000000000
--- a/gnu/packages/patches/gobject-introspection-girepository.patch
+++ /dev/null
@@ -1,25 +0,0 @@
---- a/girepository/gitypelib.c.orig
-+++ b/girepository/gitypelib.c
-@@ -2296,7 +2296,22 @@ _g_typelib_do_dlopen (GITypelib *typelib)
-         {
-           GModule *module;
- 
-+          /* 'gobject-introspection' doesn't store the path of shared
-+             libraries into '.typelib' and '.gir' files.  Shared
-+             libraries are searched for in the dynamic linker search
-+             path.  In Guix we patch 'gobject-introspection' such that
-+             it stores the absolute path of shared libraries in
-+             '.typelib' and '.gir' files.  Here, in order to minimize
-+             side effects, we make sure that if the library is not
-+             found at the indicated path location, we try with just
-+             the basename and the system dynamic library
-+             infrastructure, as per default behaviour of the
-+             library. */
-           module = load_one_shared_library (shlibs[i]);
-+          if (module == NULL && g_path_is_absolute (shlibs[i]))
-+            {
-+              module = load_one_shared_library (g_basename(shlibs[i]));
-+            }
- 
-           if (module == NULL)
-             {
