diff --git a/doc/guix.texi b/doc/guix.texi
index a66bb3d646..01e2d1ab57 100644
--- a/doc/guix.texi
+++ b/doc/guix.texi
@@ -11197,6 +11197,9 @@ The package object of the operating system kernel to use@footnote{Currently
 only the Linux-libre kernel is supported.  In the future, it will be
 possible to use the GNU@tie{}Hurd.}.
 
+@item @code{kernel-loadable-modules} (default: '())
+A list of objects (usually packages) to collect loadable kernel modules from.
+
 @item @code{kernel-arguments} (default: @code{'("quiet")})
 List of strings or gexps representing additional arguments to pass on
 the command-line of the kernel---e.g., @code{("console=ttyS0")}.
diff --git a/gnu/build/linux-modules.scm b/gnu/build/linux-modules.scm
index a149eff329..004804df36 100644
--- a/gnu/build/linux-modules.scm
+++ b/gnu/build/linux-modules.scm
@@ -22,12 +22,14 @@
   #:use-module (guix elf)
   #:use-module (guix glob)
   #:use-module (guix build syscalls)
-  #:use-module ((guix build utils) #:select (find-files))
+  #:use-module ((guix build utils) #:select (find-files invoke false-if-file-not-found))
+  #:use-module (guix build union)
   #:use-module (rnrs io ports)
   #:use-module (rnrs bytevectors)
   #:use-module (srfi srfi-1)
   #:use-module (srfi srfi-11)
   #:use-module (srfi srfi-26)
+  #:use-module (ice-9 ftw)
   #:use-module (ice-9 vlist)
   #:use-module (ice-9 match)
   #:use-module (ice-9 rdelim)
@@ -56,7 +58,9 @@
 
             write-module-name-database
             write-module-alias-database
-            write-module-device-database))
+            write-module-device-database
+
+            ensure-linux-module-directory!))
 
 ;;; Commentary:
 ;;;
@@ -631,4 +635,42 @@ be loaded on-demand, such as file system modules."
                            module devname type major minor)))
                 aliases))))
 
+(define (input-files inputs path)
+  "Given a list of directories INPUTS, return all entries with PATH in it."
+  ;; TODO: Use filter-map.
+  (filter file-exists?
+          (map (lambda (x)
+                 (string-append x path))
+               inputs)))
+
+(define (depmod! kmod inputs destination-directory output version)
+       (let ((System.maps (input-files inputs "/System.map"))
+             (Module.symverss (input-files inputs "/Module.symvers")))
+         (invoke (string-append kmod "/bin/depmod")
+                 "-e" ; Report symbols that aren't supplied
+                 "-w" ; Warn on duplicates
+                 "-b" output
+                 "-F" (match System.maps
+                       ((System.map) System.map))
+                 "-E" (match Module.symverss
+                       ((Module.symvers) Module.symvers))
+                 version)))
+
+(define (ensure-linux-module-directory! inputs output version kmod)
+  "Ensures that the directory OUTPUT...VERSION can be used by the Linux
+kernel to load modules via KMOD.  The modules to put into
+OUTPUT...VERSION are taken from INPUTS."
+  (let ((destination-directory (string-append output "/lib/modules/"
+                                              version)))
+    (when (not (file-exists? destination-directory)) ; unique
+      (union-build destination-directory
+       ;; All directories with the same version as us.
+       (filter-map (lambda (directory-name)
+                     (if (member version (scandir directory-name))
+                         (string-append directory-name "/" version)
+                         #f))
+                   (input-files inputs "/lib/modules"))
+       #:create-all-directories? #t)
+      (depmod! kmod inputs destination-directory output version))))
+
 ;;; linux-modules.scm ends here
diff --git a/gnu/local.mk b/gnu/local.mk
index 857345cfad..b25c3ceea5 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -631,6 +631,7 @@ GNU_SYSTEM_MODULES =				\
   %D%/tests/nfs.scm				\
   %D%/tests/install.scm				\
   %D%/tests/ldap.scm				\
+  %D%/tests/linux-modules.scm			\
   %D%/tests/mail.scm				\
   %D%/tests/messaging.scm			\
   %D%/tests/networking.scm			\
diff --git a/gnu/system.scm b/gnu/system.scm
index 01baa248a2..17b6e667d5 100644
--- a/gnu/system.scm
+++ b/gnu/system.scm
@@ -5,6 +5,7 @@
 ;;; Copyright © 2016 Chris Marusich <cmmarusich@gmail.com>
 ;;; Copyright © 2017 Mathieu Othacehe <m.othacehe@gmail.com>
 ;;; Copyright © 2019 Meiyo Peng <meiyo.peng@gmail.com>
+;;; Copyright © 2020 Danny Milosavljevic <dannym@scratchpost.org>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -164,6 +165,8 @@
 
   (kernel operating-system-kernel                 ; package
           (default linux-libre))
+  (kernel-loadable-modules operating-system-kernel-loadable-modules
+                    (default '()))                ; list of packages
   (kernel-arguments operating-system-user-kernel-arguments
                     (default '("quiet")))         ; list of gexps/strings
   (bootloader operating-system-bootloader)        ; <bootloader-configuration>
@@ -468,9 +471,20 @@ OS."
   "Return the basic entries of the 'system' directory of OS for use as the
 value of the SYSTEM-SERVICE-TYPE service."
   (let ((locale (operating-system-locale-directory os)))
-    (mlet %store-monad ((kernel -> (operating-system-kernel os))
-                        (initrd -> (operating-system-initrd-file os))
-                        (params    (operating-system-boot-parameters-file os)))
+    (mlet* %store-monad ((kernel -> (operating-system-kernel os))
+                         (modules ->
+                          (operating-system-kernel-loadable-modules os))
+                         (kernel
+                          ;; TODO: system, target.
+                          (profile-derivation
+                           (packages->manifest
+                            (cons kernel modules))
+                           #:hooks (list linux-module-database)
+                           #:locales? #f
+                           #:allow-collisions? #f
+                           #:relative-symlinks? #t))
+                         (initrd -> (operating-system-initrd-file os))
+                         (params    (operating-system-boot-parameters-file os)))
       (return `(("kernel" ,kernel)
                 ("parameters" ,params)
                 ("initrd" ,initrd)
diff --git a/gnu/tests/linux-modules.scm b/gnu/tests/linux-modules.scm
new file mode 100644
index 0000000000..f0e92f5c8f
--- /dev/null
+++ b/gnu/tests/linux-modules.scm
@@ -0,0 +1,102 @@
+;;; GNU Guix --- Functional package management for GNU
+;;; Copyright © 2019 Jakob L. Kreuze <zerodaysfordays@sdf.org>
+;;;
+;;; This file is part of GNU Guix.
+;;;
+;;; GNU Guix is free software; you can redistribute it and/or modify it
+;;; under the terms of the GNU General Public License as published by
+;;; the Free Software Foundation; either version 3 of the License, or (at
+;;; your option) any later version.
+;;;
+;;; GNU Guix is distributed in the hope that it will be useful, but
+;;; WITHOUT ANY WARRANTY; without even the implied warranty of
+;;; MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+;;; GNU General Public License for more details.
+;;;
+;;; You should have received a copy of the GNU General Public License
+;;; along with GNU Guix.  If not, see <http://www.gnu.org/licenses/>.
+
+(define-module (gnu tests linux-modules)
+  #:use-module (gnu packages linux)
+  #:use-module (gnu system)
+  #:use-module (gnu system vm)
+  #:use-module (gnu tests)
+  #:use-module (guix derivations)
+  #:use-module (guix gexp)
+  #:use-module (guix modules)
+  #:use-module (guix monads)
+  #:use-module (guix store)
+  #:export (%test-loadable-kernel-modules-0
+            %test-loadable-kernel-modules-1
+            %test-loadable-kernel-modules-2))
+
+;;; Commentary:
+;;;
+;;; Test in-place system reconfiguration: advancing the system generation on a
+;;; running instance of the Guix System.
+;;;
+;;; Code:
+
+(define* (module-loader-program os modules)
+  "Return an executable store item that, upon being evaluated, will dry-run
+load MODULES."
+  (program-file
+   "load-kernel-modules.scm"
+   (with-imported-modules (source-module-closure '((guix build utils)))
+     #~(begin
+         (use-modules (guix build utils))
+         (for-each (lambda (module)
+                     (invoke (string-append #$kmod "/bin/modprobe") "-n" "--" module))
+                   '#$modules)))))
+
+(define* (run-loadable-kernel-modules-test module-packages module-names)
+  "Run a test of an OS having MODULE-PACKAGES, and modprobe MODULE-NAMES."
+  (define os
+    (marionette-operating-system
+     (operating-system
+      (inherit (simple-operating-system))
+      (kernel-loadable-modules module-packages))
+     #:imported-modules '((guix combinators))))
+  (define vm (virtual-machine os))
+  (define (test script)
+    (with-imported-modules '((gnu build marionette))
+      #~(begin
+          (use-modules (gnu build marionette)
+                       (srfi srfi-64))
+          (define marionette
+            (make-marionette (list #$vm)))
+          (mkdir #$output)
+          (chdir #$output)
+          (test-begin "loadable-kernel-modules")
+          (test-assert "script successfully evaluated"
+            (marionette-eval
+             '(primitive-load #$script)
+             marionette))
+          (test-end)
+          (exit (= (test-runner-fail-count (test-runner-current)) 0)))))
+  (gexp->derivation "loadable-kernel-modules" (test (module-loader-program os module-names))))
+
+(define %test-loadable-kernel-modules-0
+  (system-test
+   (name "loadable-kernel-modules-0")
+   (description "Tests loadable kernel modules facility of <operating-system>
+with no extra modules.")
+   (value (run-loadable-kernel-modules-test '() '()))))
+
+(define %test-loadable-kernel-modules-1
+  (system-test
+   (name "loadable-kernel-modules-1")
+   (description "Tests loadable kernel modules facility of <operating-system>
+with one extra module.")
+   (value (run-loadable-kernel-modules-test
+           (list ddcci-driver-linux)
+           '("ddcci")))))
+
+(define %test-loadable-kernel-modules-2
+  (system-test
+   (name "loadable-kernel-modules-2")
+   (description "Tests loadable kernel modules facility of <operating-system>
+with two extra modules.")
+   (value (run-loadable-kernel-modules-test
+           (list acpi-call-linux-module ddcci-driver-linux)
+           '("acpi_call" "ddcci")))))
diff --git a/guix/profiles.scm b/guix/profiles.scm
index 0d38b2513f..5274a7f5c2 100644
--- a/guix/profiles.scm
+++ b/guix/profiles.scm
@@ -10,6 +10,7 @@
 ;;; Copyright © 2017 Maxim Cournoyer <maxim.cournoyer@gmail.com>
 ;;; Copyright © 2019 Kyle Meyer <kyle@kyleam.com>
 ;;; Copyright © 2019 Mathieu Othacehe <m.othacehe@gmail.com>
+;;; Copyright © 2020 Danny Milosavljevic <dannym@scratchpost.org>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -139,7 +140,9 @@
             %current-profile
             ensure-profile-directory
             canonicalize-profile
-            user-friendly-profile))
+            user-friendly-profile
+
+            linux-module-database))
 
 ;;; Commentary:
 ;;;
@@ -1137,6 +1140,50 @@ for both major versions of GTK+."
                               (hook . gtk-im-modules)))
           (return #f)))))
 
+;; XXX: Dupe in gnu/build/linux-modules.scm .
+(define (input-files inputs path)
+  "Given a list of directories INPUTS, return all entries with PATH in it."
+  ;; TODO: Use filter-map.
+  #~(begin
+      (use-modules (srfi srfi-1))
+      (filter file-exists?
+        (map (lambda (x)
+               (string-append x #$path))
+             '#$inputs))))
+
+(define (linux-module-database manifest)
+  "Return a derivation that unions all the kernel modules in the manifest
+and creates the dependency graph for all these kernel modules."
+  (mlet %store-monad ((kmod (manifest-lookup-package manifest "kmod")))
+    (define build
+      (with-imported-modules (source-module-closure '((guix build utils) (gnu build linux-modules)))
+        #~(begin
+            (use-modules (ice-9 ftw))
+            (use-modules (srfi srfi-1)) ; append-map
+            (use-modules (guix build utils)) ; mkdir-p
+            (use-modules (gnu build linux-modules))
+            (let* ((inputs '#$(manifest-inputs manifest))
+                   (module-directories #$(input-files (manifest-inputs manifest) "/lib/modules"))
+                   (directory-entries
+                    (lambda (directory-name)
+                      (scandir directory-name (lambda (basename)
+                                                (not (string-prefix? "." basename))))))
+                   ;; Note: Should usually result in one entry.
+                   (versions (append-map directory-entries module-directories)))
+                ;; TODO: if len(module-directories) == 1: return module-directories[0]
+                (mkdir-p (string-append #$output "/lib/modules"))
+                ;; Iterate over each kernel version directory (usually one).
+                (for-each (lambda (version)
+                            (ensure-linux-module-directory! inputs #$output version #$kmod))
+                          versions)
+                (exit #t)))))
+    (gexp->derivation "linux-module-database" build
+                      #:local-build? #t
+                      #:substitutable? #f
+                      #:properties
+                      `((type . profile-hook)
+                        (hook . linux-module-database)))))
+
 (define (xdg-desktop-database manifest)
   "Return a derivation that builds the @file{mimeinfo.cache} database from
 desktop files.  It's used to query what applications can handle a given
