diff --git a/gnu/local.mk b/gnu/local.mk
index 77abf61d3c..b431e4f8ce 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -2031,6 +2031,7 @@ dist_patch_DATA =						\
   %D%/packages/patches/vtk-7-gcc-10-compat.patch		\
   %D%/packages/patches/vtk-7-hdf5-compat.patch			\
   %D%/packages/patches/vtk-7-python-compat.patch		\
+  %D%/packages/patches/vulkan-loader-skip-incompatible-tests.patch	\
   %D%/packages/patches/wacomtablet-add-missing-includes.patch	\
   %D%/packages/patches/wacomtablet-qt5.15.patch			\
   %D%/packages/patches/warsow-qfusion-fix-bool-return-type.patch	\
diff --git a/gnu/packages/patches/vulkan-loader-skip-incompatible-tests.patch b/gnu/packages/patches/vulkan-loader-skip-incompatible-tests.patch
new file mode 100644
index 0000000000..92e3d03bb6
--- /dev/null
+++ b/gnu/packages/patches/vulkan-loader-skip-incompatible-tests.patch
@@ -0,0 +1,62 @@
+Certain tests that use the pre-built libraries provided in
+tests/framework/data/binaries presume they are running on a 32- or
+64-bit x86 host, as these are the only architectures for which the
+libraries are provided.
+
+Skip these tests on non-x86 platforms where the tests are certain to
+fail.
+
+diff --git a/tests/loader_regression_tests.cpp b/tests/loader_regression_tests.cpp
+index 7390596bd..1b0780c65 100644
+--- a/tests/loader_regression_tests.cpp
++++ b/tests/loader_regression_tests.cpp
+@@ -1014,6 +1014,9 @@ TEST(CreateDevice, ConsecutiveCreateWithoutDestruction) {
+ }
+ 
+ TEST(TryLoadWrongBinaries, WrongICD) {
++#if !defined(__x86_64__) && !defined(__i386__)
++    GTEST_SKIP() << "Skip this test as it is not compatible with this architecture.";
++#endif
+     FrameworkEnvironment env{};
+     env.add_icd(TestICDDetails(TEST_ICD_PATH_VERSION_2));
+     env.add_icd(TestICDDetails(CURRENT_PLATFORM_DUMMY_BINARY_WRONG_TYPE).set_is_fake(true));
+@@ -1041,6 +1044,9 @@ TEST(TryLoadWrongBinaries, WrongICD) {
+ }
+ 
+ TEST(TryLoadWrongBinaries, WrongExplicit) {
++#if !defined(__x86_64__) && !defined(__i386__)
++    GTEST_SKIP() << "Skip this test as it is not compatible with this architecture.";
++#endif
+     FrameworkEnvironment env{};
+     env.add_icd(TestICDDetails(TEST_ICD_PATH_VERSION_2));
+     env.get_test_icd().physical_devices.emplace_back("physical_device_0");
+@@ -1077,6 +1083,9 @@ TEST(TryLoadWrongBinaries, WrongExplicit) {
+ }
+ 
+ TEST(TryLoadWrongBinaries, WrongImplicit) {
++#if !defined(__x86_64__) && !defined(__i386__)
++    GTEST_SKIP() << "Skip this test as it is not compatible with this architecture.";
++#endif
+     FrameworkEnvironment env{};
+     env.add_icd(TestICDDetails(TEST_ICD_PATH_VERSION_2));
+     env.get_test_icd().physical_devices.emplace_back("physical_device_0");
+@@ -1114,6 +1123,9 @@ TEST(TryLoadWrongBinaries, WrongImplicit) {
+ }
+ 
+ TEST(TryLoadWrongBinaries, WrongExplicitAndImplicit) {
++#if !defined(__x86_64__) && !defined(__i386__)
++    GTEST_SKIP() << "Skip this test as it is not compatible with this architecture.";
++#endif
+     FrameworkEnvironment env{};
+     env.add_icd(TestICDDetails(TEST_ICD_PATH_VERSION_2));
+     env.get_test_icd().physical_devices.emplace_back("physical_device_0");
+@@ -1159,6 +1171,9 @@ TEST(TryLoadWrongBinaries, WrongExplicitAndImplicit) {
+ }
+ 
+ TEST(TryLoadWrongBinaries, WrongExplicitAndImplicitErrorOnly) {
++#if !defined(__x86_64__) && !defined(__i386__)
++    GTEST_SKIP() << "Skip this test as it is not compatible with this architecture.";
++#endif
+     FrameworkEnvironment env{};
+     env.add_icd(TestICDDetails(TEST_ICD_PATH_VERSION_2));
+     env.get_test_icd().physical_devices.emplace_back("physical_device_0");
diff --git a/gnu/packages/vulkan.scm b/gnu/packages/vulkan.scm
index b0d968938b..e9f287564c 100644
--- a/gnu/packages/vulkan.scm
+++ b/gnu/packages/vulkan.scm
@@ -222,6 +222,8 @@ (define-public vulkan-loader
              (url "https://github.com/KhronosGroup/Vulkan-Loader")
              (commit "v1.3.232")))
        (file-name (git-file-name name version))
+       (patches
+        (search-patches "vulkan-loader-skip-incompatible-tests.patch"))
        (sha256
         (base32
          "0w69sh669sx9pwlvv2rv92ds2hm2rbzsa6qqcmd8kcad0qfq7dz2"))))
