diff --git a/gnu/local.mk b/gnu/local.mk
index 1946fdcbb6..ecbae4bb53 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1930,6 +1930,7 @@ dist_patch_DATA =						\
   %D%/packages/patches/python-pytorch-runpath.patch		\
   %D%/packages/patches/python-pytorch-system-libraries.patch	\
   %D%/packages/patches/python-pytorch-1.9.0-system-libraries.patch \
+  %D%/packages/patches/python-pyvex-remove-angr-dependency.patch	\
   %D%/packages/patches/python-robotframework-atest.patch	\
   %D%/packages/patches/python-robotframework-source-date-epoch.patch \
   %D%/packages/patches/python-robotframework-sshlibrary-rf5-compat.patch \
diff --git a/gnu/packages/patches/python-pyvex-remove-angr-dependency.patch b/gnu/packages/patches/python-pyvex-remove-angr-dependency.patch
new file mode 100644
index 0000000000..dccf22bbc6
--- /dev/null
+++ b/gnu/packages/patches/python-pyvex-remove-angr-dependency.patch
@@ -0,0 +1,80 @@
+This patch removes the angr dependency from the pyvex these, thus
+resolving a circular dependency (as angr depends on pyvex). This
+patch has been taken from upstream.
+
+This patch is a squashed version of the following upstream patches:
+
+* https://github.com/angr/pyvex/commit/61fb26f223a8d8a276b702d2448a12e02c5c9c6b
+* https://github.com/angr/pyvex/commit/a1fb2a4d0826b0e43bd8bbdd00b6db032643ec95
+
+diff --git a/tests/test_spotter.py b/tests/test_spotter.py
+index 9271ccd..bed7dd4 100644
+--- a/tests/test_spotter.py
++++ b/tests/test_spotter.py
+@@ -1,6 +1,5 @@
+ import os
+ 
+-import angr
+ import archinfo
+ 
+ import pyvex
+@@ -98,53 +97,28 @@ class CortexSpotter(GymratLifter):
+ register(CortexSpotter, "ARMEL")
+ 
+ 
+-def test_full_binary():
+-    p = angr.Project(
+-        os.path.join(test_location, "armel", "RTOSDemo.axf.issue_685"),
+-        arch="ARMEL",
+-        auto_load_libs=False,
+-    )
+-    st = p.factory.call_state(0x000013CE + 1)
+-    b = st.block().vex
+-    simgr = p.factory.simulation_manager(st)
+-    simgr.step()
+-    assert b.jumpkind == "Ijk_Sys_syscall"
+-    assert simgr.active[0].regs.ip_at_syscall.args[0] == 0x13FB
+-
+-
+ def test_tmrs():
+-    test_location = str(os.path.join(os.path.dirname(os.path.realpath(__file__)), "../../binaries/tests"))
+-    p = angr.Project(
+-        os.path.join(test_location, "armel", "helloworld"),
+-        arch="ARMEL",
+-        auto_load_libs=False,
+-    )
++    arch = archinfo.arch_from_id("ARMEL")
+     ins = b"\xef\xf3\x08\x82"
+-    b = pyvex.block.IRSB(ins, 1, p.arch)
++    b = pyvex.block.IRSB(ins, 1, arch)
+     assert b.jumpkind == "Ijk_Boring"
+     assert type(b.statements[1].data) == pyvex.expr.Get
+-    assert p.arch.register_names.get(b.statements[1].data.offset, "") == "sp"
++    assert arch.register_names.get(b.statements[1].data.offset, "") == "sp"
+     assert type(b.statements[2]) == pyvex.stmt.Put
+ 
+ 
+ def test_tmsr():
+-    test_location = str(os.path.join(os.path.dirname(os.path.realpath(__file__)), "../../binaries/tests"))
+-    p = angr.Project(
+-        os.path.join(test_location, "armel", "helloworld"),
+-        arch="ARMEL",
+-        auto_load_libs=False,
+-    )
++    arch = archinfo.arch_from_id("ARMEL")
+     inss = b"\x82\xf3\x08\x88"
+-    b = pyvex.block.IRSB(inss, 1, p.arch, opt_level=3)
++    b = pyvex.block.IRSB(inss, 1, arch, opt_level=3)
+     assert b.jumpkind == "Ijk_Boring"
+     assert type(b.statements[1].data) == pyvex.expr.Get
+-    assert p.arch.register_names.get(b.statements[1].data.offset, "") == "r2"
++    assert arch.register_names.get(b.statements[1].data.offset, "") == "r2"
+     assert type(b.statements[2]) == pyvex.stmt.Put
+ 
+ 
+ if __name__ == "__main__":
+     test_basic()
+     test_embedded()
+-    test_full_binary()
+     test_tmrs()
+     test_tmsr()
diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index ba3e85fd2d..d46963c481 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -32304,6 +32304,41 @@ (define-public python-opcodes
 and BMI2).")
       (license license:bsd-2))))
 
+(define-public python-pyvex
+  (package
+    (name "python-pyvex")
+    (version "9.2.46")
+    (source
+     (origin
+       (method url-fetch)
+       (patches (search-patches "python-pyvex-remove-angr-dependency.patch"))
+       (uri (pypi-uri "pyvex" version))
+       (sha256
+        (base32 "1v64rn7gxy6fg065bgsy38z6r494k5ri5r6sn4g08hjj32ihx1ka"))))
+    (build-system pyproject-build-system)
+    (arguments
+     (list
+      #:phases #~(modify-phases %standard-phases
+                   (replace 'check
+                     (lambda* (#:key tests? #:allow-other-keys)
+                       (when tests?
+                         (with-directory-excursion "tests"
+                           (invoke "python" "-m" "unittest")))))
+
+                   (add-before 'build 'set-cc-native
+                     (lambda _
+                       (setenv "CC" "gcc")
+                       (setenv "CC_NATIVE" "gcc"))))))
+    (propagated-inputs (list python-archinfo python-bitstring python-cffi))
+    (home-page "https://github.com/angr/pyvex")
+    (synopsis "Python interface to libVEX and VEX IR")
+    (description
+     "This package provides a Python interface the libVEX and VEX IR.
+VEX is the intermediate representation (also known as intermediate
+language) used by the Valgrind analysis tool.  As such, VEX is designed
+to enable all kinds of binary analysis tasks.")
+    (license license:bsd-2)))
+
 (define-public python-archinfo
   (package
     (name "python-archinfo")
